ArticleeLife2020
High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss.
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Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
5.6field-weighted citation impact, top 5% of its field
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- On the Potential Role of Phytate Against Neurodegeneration: It Protects Against FeInternational journal of molecular sciences · 2025Article
- The Relevance of Phytate for the Treatment of Chronic Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2024Review
- Inositol Hexaphosphate in Bone Health and Disease.Biomolecules · 2024Review
- Phytate Effects on Incomplete Distal Renal Tubular Acidosis.Journal of clinical medicine · 2024Article
- The Key Role of Nutritional Intervention in Delaying Disease Progression and the Therapeutic Management of Diabetic Kidney Disease-A Challenge for Physicians and Patients.Journal of personalized medicine · 2024Review
- Can a Low-Phosphate Diet for Chronic Kidney Disease Treat Cancer? An Interdisciplinary Literature Review.Medicines (Basel, Switzerland) · 2024Review
- Effect of Phytate (InsP6) and Other Inositol-Phosphates (InsP5, InsP4, InsP3, InsP2) on Crystallization of Calcium Oxalate, Brushite, and Hydroxyapatite.Biomolecules · 2023Article
- Estimated Phytate Intake Is Associated with Bone Mineral Density in Mediterranean Postmenopausal Women.Nutrients · 2023Article
- Phytate Intake, Health and Disease: "Let Thy Food Be Thy Medicine and Medicine Be Thy Food".Antioxidants (Basel, Switzerland) · 2023Review
- Phytates as a natural source for health promotion: A critical evaluation of clinical trials.Frontiers in chemistry · 2023Review
- Phytate Dephosphorylation Products Also Act as Potent Inhibitors of Calcium Oxalate Crystallization.Molecules (Basel, Switzerland) · 2022Article
- High-Phytate Diets Increase Amyloid β Deposition and Apoptotic Neuronal Cell Death in a Rat Model.Nutrients · 2021Article
- Perspective: Plant-based Whole-Grain Foods for Chronic Kidney Disease: The Phytate-Phosphorus Conundrum.Advances in nutrition (Bethesda, Md.) · 2021Article
- Small intestinal immune-environmental changes induced by oral tolerance inhibit experimental atopic dermatitis.Cell death & disease · 2021Article
- Gamma-aminobutyric acid-salt attenuated high cholesterol/high salt diet induced hypertension in mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Article
- The Reducing Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on High-Fat Diet-Induced Pyroptosis in Endothelial and Vascular Smooth Muscle Cells of Mice Aortas.Marine drugs · 2020Article
- Research progress on applications of calcium derived from marine organisms.Scientific reports · 2020Review
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Authors and funding
25 authors at 10 institutions in 2 countries.
Ok-Hee KimDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea.
Carmen J BoothDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, United States.
Han Seok ChoiDivision of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Republic of Korea.
Jinwook LeeDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea.
Jinku KangDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea.
June HurDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea.
Woo Jin JungDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea.
Yun-Shin JungDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea.
Hyung Jin ChoiDepartment of Anatomy, Seoul National University College of Medicine, Seoul, Republic of Korea.
Hyeonjin KimDepartment of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Joong-Hyuck AuhDepartment of Food Science and Technology, Chung-Ang University, Ansung, Republic of Korea.
Jung-Wan KimDepartment of Biology, University of Incheon, Incheon, Republic of Korea.
Ji-Young ChaDepartment of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute Gachon University College of Medicine, Incheon, Republic of Korea.
Young Jae LeeDepartment of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute Gachon University College of Medicine, Incheon, Republic of Korea.
Cheol Soon LeeMedical Health Research Center, Korea University Anam Hospital, Seoul, Republic of Korea.
Cheolsoo ChoiDepartment of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea.
Yun Jae JungDepartment of Mirobiolgy, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea.
Jun-Young YangDepartment of Toxicological Evaluation and Research, Ministry of Food and Drug Safety, Cheongju-si, Republic of Korea.
Seung-Soon ImDepartment of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea.
Dae Ho LeeDepartment of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea.
Sun Wook ChoDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Young-Bum KimDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, United States.
Kyong Soo ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Young Joo ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Byung-Chul OhDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea.ORCID 0000-0002-4277-7083
Gachon University · KRSeoul National University · KRGachon University Gil Medical Center · KRBeth Israel Deaconess Medical Center · USChung-Ang University · KRIncheon National University · KRKeimyung University · KRKorea University Medical Center · KRMinistry of Food and Drug Safety · KRYale University · US
Funding
Korea Health Industry Development Institute HI14C1135Ministry of Food and Drug Safety 14182MFDS460Ministry of Food and Drug Safety 16181MFDS381National Research Foundation of Korea 2017R1D1A1B03031094National Research Foundation of Korea 2019R1A2C2008130
Abstract
Phosphate overload contributes to mineral bone disorders that are associated with crystal nephropathies. Phytate, the major form of phosphorus in plant seeds, is known as an indigestible and of negligible nutritional value in humans. However, the mechanism and adverse effects of high-phytate intake on Ca
Indexed as
Animal FeedAnimalsBone and BonesCalciumCalcium, DietaryDietFemaleMaleMineralsPhosphatesPhosphorusPhytic AcidRats, Sprague-DawleyRenal Insufficiency, ChronicRisk FactorsCalciumCalcium, DietaryMineralsPhosphatesPhosphorusPhytic Acidcalciumcrystal nephropathieshuman biologyhypophosphatemiakidney stonesmedicinephosphate overloadphytaterat
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.