ArticleThe American journal of managed care2020
High-cost, high-need patients: the impact of reported penicillin allergy.
Article in The American journal of managed care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Improving surgical antimicrobial prophylaxis in patients with a penicillin allergy label: a quality improvement study.BMJ open quality · 2026Article
- Association of a Reported Penicillin Allergy Label With Clinical Outcomes in Alcohol-Associated Liver Disease.Alcohol, clinical & experimental research · 2026Article
- The effect of polyallergy on ancillary service use among postoperative patients with gynecologic malignancies.Gynecologic oncology reports · 2026Article
- Outcomes in hospitalised patients with penicillin allergy: a systematic review and meta-analysis protocol.Systematic reviews · 2026Article
- De-Labelling Penicillin Allergies in the Paediatric Emergency Department.Antibiotics (Basel, Switzerland) · 2025Review
- Surgical Site Infection after Primary Open Surgery for Laryngeal Cancer in a Tertiary Hospital in Belgrade, Serbia: A 10-Year Prospective Cohort Study.Antibiotics (Basel, Switzerland) · 2024Article
- Examining Antimicrobial Stewardship Program Implementation in Carceral Settings.AMA journal of ethics · 2024Article
- Assessing the rationale of prescribing carbapenems among hospitalized patients with documented penicillin allergy: implications for stewardship.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes.BMC pregnancy and childbirth · 2023Article
- A multidisciplinary approach to verify and de-label of drug allergic histories in a university hospital in Thailand: a retrospective descriptive study.Journal of pharmaceutical policy and practice · 2023Article
- How Well Are Pharmacists Represented in National Institutes of Health R01 Funding to United States Schools of Pharmacy?Pharmacy (Basel, Switzerland) · 2022Article
- Characterization, epidemiology and risk factors of multiple drug allergy syndrome and multiple drug intolerance syndrome: A systematic review.Clinical and translational allergy · 2022Article
- Epidemiological and Microbiological Aspects of the Peritonsillar Abscess.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesMore than 90% of patients who report a penicillin allergy have the allergy disproved when tested. Unnecessary use of alternative (non-beta-lactam) antibiotics can result in more treatment failures and adverse reactions. We described the prevalence and impact of a reported penicillin allergy in high-cost, high-need (HCHN) patients. STUDY
designRetrospective cohort.
methodsWe identified HCHN patients in a care management program of an urban academic medical center (January 1, 2014, to December 31, 2016). We used multivariable logistic regression models to determine the association between a reported penicillin allergy and antibiotic use. We used multivariable Poisson regression models to determine the association between a reported penicillin allergy, with or without multiple drug intolerance syndrome (MDIS; ≥3 reported drug allergies), and healthcare resource utilization (HRU).
resultsOf 1870 HCHN patients, 383 (20%) reported penicillin allergy, 835 (45%) had MDIS, and 290 (16%) had both. HCHN patients reporting penicillin allergy had an increased odds of beta-lactam alternative antibiotic use (adjusted odds ratio, 3.84; 95% CI, 2.17-6.80). HRU was significantly higher for patients reporting a penicillin allergy alone (adjusted relative risk [aRR], 1.13; 95% CI, 1.03-1.25) and with concurrent MDIS (aRR, 1.20; 95% CI, 1.08-1.34).
conclusionsHCHN patients had a high burden of reported drug allergy. A reported penicillin allergy conferred a 4-fold increased odds of beta-lactam alternative antibiotic use. Reporting penicillin allergy, with and without MDIS, was associated with significantly more HRU. HCHN care management programs should consider systematic drug allergy evaluations to optimize antibiotic use in these fragile patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.