Evidence map›Paper›PMID 32270584›Full record

ArticleJournal of biomedical materials research. Part A2020

Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility.

Kimberly A Spaulding, Yang Zhu, Kiyoaki Takaba, Anusuya Ramasubramanian, Anusha Badathala, Henrik Haraldsson, Alexander Collins, Esteban Aguayo, Curran Shah, Arthur W Wallace and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part A, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Kimberly A SpauldingVeterans Affairs Medical Center, San Francisco, California, USA.
Yang ZhuDepartment of Bioengineering and Materials Science and Engineering, University of California at Berkeley, California, USA.ORCID 0000-0002-7384-607X
Kiyoaki TakabaVeterans Affairs Medical Center, San Francisco, California, USA.
Anusuya RamasubramanianDepartment of Bioengineering and Materials Science and Engineering, University of California at Berkeley, California, USA.
Anusha BadathalaVeterans Affairs Medical Center, San Francisco, California, USA.
Henrik HaraldssonVeterans Affairs Medical Center, San Francisco, California, USA.
Alexander CollinsVeterans Affairs Medical Center, San Francisco, California, USA.
Esteban AguayoVeterans Affairs Medical Center, San Francisco, California, USA.
Curran ShahDepartment of Bioengineering and Materials Science and Engineering, University of California at Berkeley, California, USA.
Arthur W WallaceVeterans Affairs Medical Center, San Francisco, California, USA.
Nicholas P ZiatsDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
David H LovettVeterans Affairs Medical Center, San Francisco, California, USA.
Anthony J BakerVeterans Affairs Medical Center, San Francisco, California, USA.
Kevin E HealyDepartment of Bioengineering and Materials Science and Engineering, University of California at Berkeley, California, USA.
Mark B RatcliffeVeterans Affairs Medical Center, San Francisco, California, USA.
San Francisco VA Medical Center · USUniversity of California, Berkeley · USCase Western Reserve University · US

Funding

QUANTITATIVE ANALYSIS OF LEFT VENTRICULPLASTY--CHFR01HL063348 · NHLBI · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI RATCLIFFE, MARK B · 2000 to 2017
$6.8M
Surgery for Ischemic Mitral RegurgitationR01HL084431 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI RATCLIFFE, MARK B · 2008 to 2011
$2.5M
Right Heart Function in Health and Chronic Lung DiseaseI01BX000740 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI Anthony J. BAKER · 2011 to 2026
–
BLRD VA I01 BX000740NHLBI NIH HHS R01 HL063348NHLBI NIH HHS R01 HL084431
6 · The paper itself

Abstract

The decrease in contractility in myocardium adjacent (border zone; BZ) to a myocardial infarction (MI) is correlated with an increase in reactive oxygen species (ROS). We hypothesized that injection of a thermoresponsive hydrogel, with ROS scavenging properties, into the MI would decrease ROS and improve BZ function. Fourteen sheep underwent antero-apical MI. Seven sheep had a comb-like copolymer synthesized from N-isopropyl acrylamide (NIPAAm) and 1500 MW methoxy poly(ethylene glycol) methacrylate, (NIPAAm-PEG1500), injected (20 × 0.5 mL) into the MI zone 40 min after MI (MI + NIPAAm-PEG1500) and seven sheep were MI controls. Cardiac MRI was performed 2 weeks before and 6 weeks after MI + NIPAAm-PEG1500. BZ wall thickness at end systole was significantly higher for MI + NIPAAm-PEG1500 (12.32 ± 0.51 mm/m

Indexed as

AcrylamidesAnimalsFree Radical ScavengersHydrogelsInjectionsMyocardial ContractionMyocardial InfarctionPolyethylene GlycolsReactive Oxygen SpeciesSheepAcrylamidesFree Radical ScavengersHydrogelsN-isopropylacrylamidePolyethylene GlycolsReactive Oxygen Specieshydrogelmatrix metalloproteinases-2myocardial contractionmyocardial infarctionreactive oxygen species

Identifiers

PMID32270584
PMCPMC8174154
OpenAlexW3015423560

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.