ReviewJournal of veterinary pharmacology and therapeutics2020
Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine.
Review in Journal of veterinary pharmacology and therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- How much Copper Do Calves Need? Retention and Hepatic Storage in Artificially Reared Milk-Fed Holstein-Friesian Calves.Biological trace element research · 2026Article
- Large Animal Models for Preclinical Evaluation of Heart Valve Prostheses, Left Ventricular Assist Devices and Total Artificial Hearts: A Narrative Review.Biomimetics (Basel, Switzerland) · 2026Review
- Dose Optimization of Tilmicosin againstJournal of agricultural and food chemistry · 2026Article
- Tissue distribution and quantification of bovine leukemia virus proviral DNA in cows after a long-term infection with wild-type strains and the attenuated BLV vaccine strain.Frontiers in immunology · 2026Article
- Applications of PBPK Models to Predict Tissue Residues and Extralabel Withdrawal Times of Drugs in Food Animals: Perspectives from the Food Animal Residue Avoidance Databank (FARAD) Program.The AAPS journal · 2025Review
- A Daily Accumulation Model for Predicting PFOS Residues in Beef Cattle Muscle After Oral Exposure.Toxics · 2025Article
- Development of Glutathione Hydrogel Carriers Containing Zinc Oxide Microparticles for Skin Regeneration Processes.International journal of molecular sciences · 2025Article
- Experimental animal models of acute respiratory distress syndrome: one-hit and two-hit establishment application.Frontiers in immunology · 2025Review
- Review
- Pathology of African Swine Fever in Wild Boar Carcasses Naturally Infected with German Virus Variants.Pathogens (Basel, Switzerland) · 2022Article
- An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin G.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Apply a Physiologically Based Pharmacokinetic Model to Promote the Development of Enrofloxacin Granules: Predict Withdrawal Interval and Toxicity Dose.Antibiotics (Basel, Switzerland) · 2021Article
- Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part III: Sheep and goat.Journal of veterinary pharmacology and therapeutics · 2021Review
- Application of a Physiologically Based Pharmacokinetic Model to Develop a Veterinary Amorphous Enrofloxacin Solid Dispersion.Pharmaceutics · 2021Article
- Modelling Shows the Negative Impact of Age Dependent Pharmacokinetics on the Efficacy of Oxytetracycline in Young Steers.Frontiers in veterinary science · 2021Article
- Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part II: Chicken and turkey.Journal of veterinary pharmacology and therapeutics · 2020Review
- Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine.Journal of veterinary pharmacology and therapeutics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Physiologically based pharmacokinetic (PBPK) models for chemicals in food animals are a useful tool in estimating chemical tissue residues and withdrawal intervals. Physiological parameters such as organ weights and blood flows are an important component of a PBPK model. The objective of this study was to compile PBPK-related physiological parameter data in food animals, including cattle and swine. Comprehensive literature searches were performed in PubMed, Google Scholar, ScienceDirect, and ProQuest. Relevant literature was reviewed and tables of relevant parameters such as relative organ weights (% of body weight) and relative blood flows (% of cardiac output) were compiled for different production classes of cattle and swine. The mean and standard deviation of each parameter were calculated to characterize their variability and uncertainty and to allow investigators to conduct population PBPK analysis via Monte Carlo simulations. Regression equations using weight or age were created for parameters having sufficient data. These compiled data provide a comprehensive physiological parameter database for developing PBPK models of chemicals in cattle and swine to support animal-derived food safety assessment. This work also provides a basis to compile data in other food animal species, including goats, sheep, chickens, and turkeys.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.