ReviewInfection2020
Treatment of fracture-related infection of the lower extremity with antibiotic-eluting ceramic bone substitutes: case series of 35 patients and literature review.
Review in Infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Translation-driven design: development of an antibiotic-loaded hydrogel for the management of orthopaedic device-related infection.Bioactive materials · 2026Article
- Reported practice patterns in the use of local antibiotics for fracture-related infection among SICOT respondents: an international survey.BMC musculoskeletal disorders · 2026Article
- Antibiotic Selection for Sustained Local Therapy May Be Important to ReduceMicroorganisms · 2026Article
- A promising therapeutic biomaterial: CHX@ZnO-HA/PSSS nanocomposites enable pH-Dependent infection eradication and bone regeneration in osteomyelitis.Journal of Taibah University Medical Sciences · 2026Article
- Article
- Non‑contact locking plate: A useful alternative to external fixation in second‑stage treatment of post‑traumatic tibial osteomyelitis.Experimental and therapeutic medicine · 2024Article
- Key aspects of soft tissue management in fracture-related infection: recommendations from an international expert group.Archives of orthopaedic and trauma surgery · 2024Review
- Micro-Structural and Biomechanical Evaluation of Bioresorbable and Conventional Bone Cements for Augmentation of the Proximal Femoral Nail.Journal of clinical medicine · 2023Article
- New insights in lower limb reconstruction strategies.Therapeutic advances in musculoskeletal disease · 2023Review
- Does the Use of Local Antibiotics Affect Clinical Outcome of Patients with Fracture-Related Infection?Antibiotics (Basel, Switzerland) · 2022Article
- Comment on Niemann et al. Outcome Analysis of the Use of CeramentDiagnostics (Basel, Switzerland) · 2022Article
- Complications of the surgical treatment of fractures of the tibial plateau: prevalence, causes, and management.EFORT open reviews · 2022Review
- What Factors Affect Outcome in the Treatment of Fracture-Related Infection?Antibiotics (Basel, Switzerland) · 2022Article
- Continuous Local Antibiotic Perfusion (CLAP) for Post-operative Infection of Open Tibial Fractures: A Case Report.Journal of orthopaedic case reports · 2022Article
- The use of negative pressure wound therapy for fracture-related infections following internal osteosynthesis of the extremity: A systematic review.Journal of clinical orthopaedics and trauma · 2022Review
- Promotion of a damage control concept in repairing orthopedic lower limb trauma.American journal of translational research · 2022Article
- The Efficacy of Rehabilitation Nursing Interventions on Patients with Open Lower Limb Fractures.Journal of healthcare engineering · 2022Article
- Surgical Treatment of Clavicular Fractures, Refractures, Delayed and Non-Unions Using a Resorbable, Gentamicin-Eluting Calcium Sulphate/Hydroxyapatite Biocomposite.Therapeutics and clinical risk management · 2022Article
- Treatment of Chronic Osteomyelitis of the Femur by Intramedullary Antibiotic Perfusion (iMAP): A Case Report.Journal of orthopaedic case reports · 2021Article
- Comment on "Bioactive glass S53P4 vs. autologous bone graft for filling defects in patients with chronic osteomyelitis and infected non-unions - a single center experience" by Steinhausen et al. (2021).Journal of bone and joint infection · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe current treatment concepts of fracture-related infection (FRI) [Consensus Conference (Anti-Infection Task Force (AITF)) on the definition of acute or chronic osteomyelitis (cOM)] are associated with unsolved challenges and problems, underlining the need for ongoing medical research.
methodLiterature review of treatments for FRI and description of own cases.
resultsWe could include eight papers with 394 patients reporting treatments and outcome in FRI. The infection was resolved in 92.9% (mean) of all treatments. The mean follow-up was 25 months with a persistent non-union in 7% of the patients. We diagnosed 35 (19f/16m; 56.4 ± 18.6 years) patients with bone infections anatomically allocated to the proximal and distal femur (12×), the pelvis (2×), distal tibia (3×), tibial diaphysis (11×), the ankle joint (4×) and calcaneus (3×). These 35 patients were treated (1) with surgical debridement; (2) with antibiotic-eluting ceramic bone substitutes; (3) bone stabilization (including nail fixation, arthrodesis nails, plates, or external ring fixation), (4) optionally negative pressure wound therapy (NPWT) and (5) optionally soft tissue closure with local or free flaps. The mean follow-up time was 14.9 ± 10.6 months (min/max: 2/40 month). The overall recurrence rate is low (8.5%, 3/35). Prolonged wound secretion was observed in six cases (17.1%, 6/35). The overall number of surgeries was a median of 2.5.
conclusionThe results in the literature and in our case series are explicitly promising regarding the treatment of posttraumatic fracture-related infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.