Evidence map›Paper›PMID 32270406›Full record

SynthesisClinical autonomic research : official journal of the Clinical Autonomic Research Society2021

Exercise-based cardiac rehabilitation and parasympathetic function in patients with coronary artery disease: a systematic review and meta-analysis.

Agustín Manresa-Rocamora, Fernando Ribeiro, José Manuel Sarabia, Javier Íbias, Nórton Luís Oliveira, Francisco José Vera-García, Manuel Moya-Ramón

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  8. Exercise-based cardiac rehabilitation for coronary heart disease.The Cochrane database of systematic reviews · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Agustín Manresa-RocamoraSport Research Centre, Miguel Hernandez University, Avenida de la Universidad s/n, 03202, Elche, Spain.
Fernando RibeiroSchool of Health Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, Building 30, Agras do Crasto-Campus Universita ́rio de Santiago, 3810-193, Aveiro, Portugal.
José Manuel SarabiaSport Research Centre, Miguel Hernandez University, Avenida de la Universidad s/n, 03202, Elche, Spain.
Javier ÍbiasDepartment of Behavioral Sciences and Methodology, Faculty of Psychology, National Distance Education University (UNED), Juan del Rosal 10, 28040, Madrid, Spain.
Nórton Luís OliveiraNational Institute of Science and Technology for Health Technology Assessment (IATS/HCPA) and Exercise Pathophysiology Laboratory, Hospital de Clínicas de Porto Alegre, Clinical Research Center, Rua Ramiro Barcelos 2350, Porto Alegre, RS, Brazil.
Francisco José Vera-GarcíaSport Research Centre, Miguel Hernandez University, Avenida de la Universidad s/n, 03202, Elche, Spain.
Manuel Moya-RamónSport Research Centre, Miguel Hernandez University, Avenida de la Universidad s/n, 03202, Elche, Spain. mmoya@umh.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe effects of exercise-based cardiac rehabilitation (CR) on parasympathetic modulation are controversial. This systematic review and meta-analysis aims to (a) determine the effect of exercise-based CR on heart-rate-derived indices associated with cardiac parasympathetic modulation in resting and post-exercise conditions in coronary artery disease (CAD) patients and (b) identify the possible moderator variables of the effect of exercise-based CR on parasympathetic modulation.

methodsWe searched CENTRAL and Web of Science up to November 2018 for the following terms: adult CAD patients, controlled exercise-based CR interventions and parasympathetic modulation measured in resting (vagal-related heart rate variability [HRV] indices of the root mean square of the differences in successive in RR interval [RMSSD] and high frequency [HF]) and post-exercise (heart rate recovery [HRR]) pre- and post-intervention. We estimated a random-effects model of standardised mean difference (SMD) and mean difference (MD) for vagal-related HRV indices and HRR, respectively. We assessed the influence of categorical and continuous variables.

resultsThe overall effect size showed significant differences in RMSSD (SMD

conclusionsExercise-based CR improves the post-exercise parasympathetic function, with greater effects in younger CAD patients and in those who were revascularised with percutaneous intervention. The effects on resting parasympathetic function are more controversial due to methodological inconsistencies in measuring HRV, with the use of RMSSD recommended instead of HF because its results show higher consistency. Future studies involving women, focusing on methodological issues, and performing other training methods are needed to increase our knowledge about this topic.

Indexed as

Cardiac RehabilitationCoronary Artery DiseaseAdultExerciseFemaleHeartHeart RateHumansAcute myocardial infarctionAerobic trainingAutonomic nervous systemCoronary heart diseaseResistance training

Identifiers

PMID32270406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.