Evidence map›Paper›PMID 32270338›Full record

ArticleMikrochimica acta2020

Electrochemical immunoassay for the carcinoembryonic antigen based on Au NPs modified zeolitic imidazolate framework and ordered mesoporous carbon.

Yingcong Zhang, Ze Zhang, Shengzhong Rong, Hongwei Yu, Hongmin Gao, Ping Ding, Dong Chang, Hongzhi Pan

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yingcong ZhangDepartment of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University, Shanghai, 200000, People's Republic of China.
Ze ZhangDepartment of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University, Shanghai, 200000, People's Republic of China.
Shengzhong RongDepartment of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University, Shanghai, 200000, People's Republic of China.
Hongwei YuDepartment of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University, Shanghai, 200000, People's Republic of China.
Hongmin GaoSchool of Public Health, Wuhan University of Science and Technology, Wuhan, HuBei Province, 430065, People's Republic of China.
Ping DingXiang Ya School of Public Health, Central South University, Changsha, 410078, People's Republic of China.
Dong ChangDepartment of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University, Shanghai, 200000, People's Republic of China. changdongydy@163.com.
Hongzhi PanCollaborative Research Center, Shanghai University of Medicine and Health Sciences, Shanghai, 201399, People's Republic of China. panhongzhi@163.com.

Funding

Fundamental Research Funds for the Universities of Heilongjiang Province 2017-KYYWF-0648Major weak subjects in Pudong New area PWZbr2017-02National Natural Science Foundation of China 81673229National Natural Science Foundation of China 81773480, 81573200National Natural Science Fund of China 81973097National Outstanding Youth Science Fund Project of National Natural Science Foundation of China (CN) 81703269Natural Science Foundation of Heilongjiang Province QC2018120Shanghai Pudong Hospital Talent Project PX201604the Administration of Science & Technology Foundation of Mudanjiang No. Z2016s0072University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province UNPYSCT-2017173
6 · The paper itself

Abstract

An electrochemical immunoassay for the carcinoembryonic antigen is described. It is based on the use of Au NPs modified zeolitic imidazolate framework (ZIF-8) and ordered mesoporous carbon (OMC). Au NPs@ZIF-8 was synthesized by reduction of chloroauric acid. It serves as immobilization support nanocarrier to increase antibody loading due to its large surface area. OMC was dropped on a glassy carbon electrode to improve electrochemical signals due to enhanced electrical conductivity. Differential pulse voltammetry was carried out to record electrochemical responses (best measured at 0.26 V vs. Ag/AgCl). The immunosensor demonstrated excellent electrochemical performance with a linear determination range of 5 pg mL

Indexed as

Antibodies, ImmobilizedCarbonCarcinoembryonic AntigenElectrochemical TechniquesGoldHumansImmunoassayLimit of DetectionMetal NanoparticlesMetal-Organic FrameworksPorosityReproducibility of ResultsAntibodies, ImmobilizedCarbonCarcinoembryonic AntigenGoldMetal-Organic FrameworksCEAGold nanoparticlesImmunosensorZIF-8

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.