ArticleQuantitative imaging in medicine and surgery2020
Fast kilovoltage (KV)-switching dual-energy computed tomography hydroxyapatite (HAP)-water decomposition technique for identifying bone marrow edema in vertebral compression fractures.
Article in Quantitative imaging in medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 16 citations in OpenAlex.
- Fast kilovoltage peak-switching dual-energy computed tomography water-hydroxyapatite decomposition for detecting vertebral compression fracture-related bone marrow edema: a comparison with magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Risk factors for lumbar fascial edema in patients with osteoporotic vertebral compression fractures and its effect on residual pain after percutaneous vertebroplasty.American journal of translational research · 2025Article
- Toward the Application of Dual-Energy Computed Tomography with Virtual Non-Hydroxyapatite Color-Coded Maps to Identify Traumatic Fractures in Daily Emergency Settings.Journal of imaging · 2024Article
- The value of quantitative analysis of radionuclide bone SPECT/CT imaging in vertebral compression fracture: a retrospective study.BMC medical imaging · 2024Article
- Detecting bone marrow infiltration in nonosteolytic multiple myeloma through separation of hydroxyapatite via the two-material decomposition technique in spectral computed tomography.Quantitative imaging in medicine and surgery · 2024Article
- Advances in Bone Marrow Imaging: Strengths and Limitations from a Clinical Perspective.Seminars in musculoskeletal radiology · 2023Article
- Utilization of a two-material decomposition from a single-source, dual-energy CT in acute traumatic vertebral fractures.Frontiers in radiology · 2023Article
- Rapid-kilovoltage-switching dual-energy computed tomography (CT) for differentiating spinal osteolytic metastases from spinal infections.Quantitative imaging in medicine and surgery · 2021Article
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11 authors at 2 institutions in 1 country.
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Abstract
backgroundHydroxyapatite (HAP) is the main component of bone mineral. The utility of using HAP-water decomposition technique with fast kilovoltage (KV)-switching dual-energy computed tomography (DECT) to detect abnormal edema in vertebral compression fractures (VCFs) has not been widely reported.
methodsA total of 31 consecutive patients with 80 VCFs who underwent DECT and magnetic resonance imaging (MRI) of the spine were retrospectively enrolled in our study between October 2018 and January 2019. VCFs in MR examinations served as the standard of reference. Two radiologists blindly and independently evaluated color-coded overlay virtual nonhydroxyapatite (VNHAP) images for the presence of abnormal edema. The inter-reader agreement, specificity, sensitivity, accuracy, and predictive values of VNHAP images for edema detection were calculated. The diagnostic accuracy of two readers was compared using McNemar's test. Two additional radiologists performed a quantitative analysis on VNHAP images, receiver operating characteristic (ROC) curve analysis was conducted, and the threshold was calculated.
resultsMRI depicted 45 edematous and 35 nonedematous VCFs. For visual analysis, the VNHAP technique showed a sensitivity of 93.3%, a specificity of 97.1%, a positive predictive value (PPV) of 97.7%, a negative predictive value (NPV) of 91.9%, and an accuracy of 95.0%. The inter-reader agreement was almost perfect (k=0.90). The diagnostic accuracy of the two readers showed no significant differences in the assessment of VNHAP images (P=1.00). Significant differences in CT numbers between vertebrae with and without bone marrow edema were found by quantitative analysis (P<0.01). The area under the curve (AUC) of the VNHAP images was estimated to be 0.917. The threshold of 1,003.2 mg/cm
conclusionsFast KV-switching DECT HAP-water decomposition technique had excellent diagnostic performance for identifying acute and chronic VCFs in visual and quantitative analyses.
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