Evidence map›Paper›PMID 32269850›Full record

ArticleInternational journal of sports physical therapy2020

EFFECT OF AEROBIC EXERCISE TRAINING WITH AND WITHOUT BLOOD FLOW RESTRICTION ON AEROBIC CAPACITY IN HEALTHY YOUNG ADULTS: A SYSTEMATIC REVIEW WITH META-ANALYSIS.

Magno F Formiga, Rebekah Fay, Savannah Hutchinson, Nicholas Locandro, Angel Ceballos, Alexandra Lesh, Joel Buscheck, Jacy Meanor, Johnny G Owens, Lawrence P Cahalin

Erratum issued Registry-linked trialAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of sports physical therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07079280 (Comparison of Acute Micro- and Macrovascular Responses to Aerobic Exercise With and Without Blood Flow Restriction in Young and Older Adults), which is not on this map. Cited by 46 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07079280 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Comparison of Acute Micro- and Macrovascular Responses to Aerobic Exercise With and Without Blood Flow Restriction in Young and Older Adults: A Randomized Crossover Trial.

TypeinterventionalSponsorEgas Moniz - Cooperativa de Ensino Superior, CRLRan2025 to 2026Enrolled52ConditionsAgeing, Blood Flow Restriction (BFR) Training EffectsArmsLow Intensity Aerobic Exercise with Blood Flow Restriction (LIAE+BFR), High Intensity Interval Exercise (HIIE)
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Magno F Formiga
Rebekah FayDepartment of Physical Therapy, Miller School of Medicine, University of Miami, Coral Gables, FL, USA.
Savannah HutchinsonDepartment of Physical Therapy, Miller School of Medicine, University of Miami, Coral Gables, FL, USA.
Nicholas LocandroDepartment of Physical Therapy, Miller School of Medicine, University of Miami, Coral Gables, FL, USA.
Angel CeballosDepartment of Physical Therapy, Miller School of Medicine, University of Miami, Coral Gables, FL, USA.
Alexandra LeshDepartment of Physical Therapy, Miller School of Medicine, University of Miami, Coral Gables, FL, USA.
Joel BuscheckDepartment of Physical Therapy, Miller School of Medicine, University of Miami, Coral Gables, FL, USA.
Jacy MeanorDepartment of Physical Therapy, Miller School of Medicine, University of Miami, Coral Gables, FL, USA.
Johnny G OwensOwens Recovery Science, San Antonio, TX, USA.
Lawrence P CahalinDepartment of Physical Therapy, Miller School of Medicine, University of Miami, Coral Gables, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise training (ET) with blood flow restriction (BFR) is becoming increasingly popular, but the majority of BFR ET studies have evaluated skeletal muscle strength and hypertrophy. The favorable effect of BFR ET on skeletal muscle and the vasculature appears to improve aerobic capacity (AC) although conflicting results have been observed.Purpose: The purposes of this systematic review with meta- analysis were to examine the effects of aerobic ET with and without BFR on AC and to compare the effect of low-to-moderate aerobic ET with and without BFR to high-intensity aerobic ET with and without BFR on AC. STUDY

designSystematic Review with Meta-analysis.

methodsA comprehensive search for studies examining the effects of aerobic ET with and without BFR on AC was performed. Inclusion criteria were: (a) the study was conducted in healthy individuals, (b) there was random allocation of study participants to training and control groups, (c) BFR was the sole intervention difference between the groups.

resultsA total of seven studies (5 low-to-moderate ET and 2 high-intensity ET) were included in the meta-analysis providing data from 121 subjects. There was a significant standardized mean difference (SMD) of 0.38 (95% CI = 0.01, 0.75) in AC between the BFR and non-BFR groups of all seven studies (z = 2.01; p = 0.04). Separate analyses of the five low-to-moderate aerobic ET studies found similar results with aerobic ET with BFR eliciting a significantly greater AC (z = 2.47; p=0.01) than aerobic ET without BFR (SMD of 0.57; 95% CI = 0.12, 1.01). Separate analyses of the two high-intensity aerobic ET studies with and without BFR found no significant difference in AC between the groups (SMD of - 0.01; 95% CI = - 0.67, 0.64).

conclusionAerobic ET with BFR elicits a significantly greater AC than aerobic ET without BFR in healthy young adults. However, low-to-moderate intensity aerobic ET with BFR elicited a greater improvement in AC than aerobic ET without BFR while high-intensity aerobic ET with BFR did not elicit an improvement in AC over high-intensity aerobic ET without BFR. LEVEL OF EVIDENCE: 1a.

Indexed as

aerobic capacityblood flow restrictionmaximal oxygen consumptionmeta-analysisoxygen uptakevascular occlusion trainingVO2max.

Identifiers

PMID32269850
PMCPMC7134358

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.