Evidence map›Paper›PMID 32269849›Full record

ArticleJournal of gastric cancer2020

Bilateral Breast Metastases from Epstein-Barr Virus-Associated Gastric Cancer during Pregnancy: Is There a Method to Its Madness?

Erica Quaquarini, Alessandro Vanoli, Mara Frascaroli, Alessandra Viglio, Marco Lucioni, Daniele Presti, Gessica Lobascio, Andrea Pietrabissa, Antonio Bernardo, Marco Paulli

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastric cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Erica QuaquariniMedical Oncology Unit, IRCCS ICS Maugeri SpA SB, Pavia, Italy.ORCID https://orcid.org/0000-0001-9099-5352
Alessandro VanoliAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia, Pavia, Italy.ORCID https://orcid.org/0000-0002-2976-7032
Mara FrascaroliTranslational Oncology Unit, IRCCS ICS Maugeri SpA SB, Pavia, Italy.ORCID https://orcid.org/0000-0002-7392-2909
Alessandra ViglioAnatomic Pathology Unit, IRCCS San Matteo Hospital Foundation, Pavia, Italy.
Marco LucioniAnatomic Pathology Unit, IRCCS San Matteo Hospital Foundation, Pavia, Italy.
Daniele PrestiMedical Oncology Unit, IRCCS ICS Maugeri SpA SB, Pavia, Italy.ORCID https://orcid.org/0000-0003-4442-6700
Gessica LobascioAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia, Pavia, Italy.ORCID https://orcid.org/0000-0001-7327-4553
Andrea PietrabissaDepartment of Clinical-Surgical, Diagnostic and Pediatric Sciences, Unit of General Surgery 2, University of Pavia and IRCCS San Matteo Hospital Foundation, Pavia, Italy.ORCID https://orcid.org/0000-0001-9703-7587
Antonio BernardoMedical Oncology Unit, IRCCS ICS Maugeri SpA SB, Pavia, Italy.ORCID https://orcid.org/0000-0002-2751-2626
Marco PaulliAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia, Pavia, Italy.
University of Pavia · ITIstituti Clinici Scientifici Maugeri · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity Hospital Foundation · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast metastases of extramammary malignant neoplasms are rare, with an incidence of 0.3%-2.7% among all malignant mammary tumors. Breast metastases from gastric carcinoma are very rare (<0.1%), and this event is even rarer during pregnancy. Herein, we describe a 39-year-old Caucasian woman with a history of an Epstein-Barr virus-associated gastric carcinoma (EBVaGC) that was characterized by prominent tumor infiltrating lymphocytes. Three years after undergoing radical surgery, the patient developed bilateral breast nodules during her pregnancy. A breast biopsy was performed, and histology confirmed a diagnosis of EBVaGC; tumor cells showed positivity for cytokeratin 8/18 and E-cadherin, and negativity for cytokeratin 7, cytokeratin 20, cytokeratin 5/6, caudal type homebox 2, androgen receptor, mammaglobin, gross cystic disease fluid protein-15, and estrogen and progesterone receptors. We also discuss the main diagnostic pitfalls. To our knowledge, this is the first report of an EBVaGC with lymphoid stroma that developed breast metastases during pregnancy.

Indexed as

Epstein-Barr virusGastric cancerNeoplasm metastasisPregnancyTumor-infiltrating lymphocytes

Identifiers

PMID32269849
PMCPMC7105417
OpenAlexW2974783727

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.