Evidence map›Paper›PMID 32269836›Full record

ArticleNeuronal signaling2019

Modulation of CRMP2 via (

Katherine A White, Jacob T Cain, Helen Magee, Seul Ki Yeon, Ki Duk Park, Rajesh Khanna, Jill M Weimer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuronal signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neuronal signaling · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katherine A WhitePediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, U.S.A.
Jacob T CainPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, U.S.A.
Helen MageePediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, U.S.A.
Seul Ki YeonConvergence Research Center for Dementia, Brain Science Institute, Korea Institute of Science and Technology, Seoul, South Korea.
Ki Duk ParkConvergence Research Center for Dementia, Brain Science Institute, Korea Institute of Science and Technology, Seoul, South Korea.
Rajesh KhannaDepartment of Pharmacology, University of Arizona, Tucson, AZ, U.S.A.
Jill M WeimerPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, U.S.A.ORCID 0000-0003-2504-4942

Funding

Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2M
The Impact of PD-1 Inhibition on Immune-Response to ChemoradiotherapyP20GM103548 · NIGMS · SANFORD RESEARCH/USD · PI MISKIMINS, W KEITH · 2012 to 2020
$20.8M
Novel mechanisms for distal transport in developing and mature neuronsR01NS082283 · NINDS · SANFORD RESEARCH/USD · PI WEIMER, JILL M · 2014 to 2018
$1.9M
NIGMS NIH HHS P20 GM103548NIGMS NIH HHS P20 GM103620NINDS NIH HHS R01 NS082283
6 · The paper itself

Abstract

CLN6-Batten disease is a rare neurodegenerative disorder with no cure, characterized by accumulation of lipofuscin in the lysosome, glial activation, and neuronal death. Here we test the therapeutic efficacy of modulating collapsin response mediator protein 2 (CRMP2) activity via

Indexed as

Batten diseaseCRMP2Lacosamideneuronal ceroid lipofuscinosisrepurposed pharmaceuticals

Identifiers

PMID32269836
PMCPMC7104323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.