ArticleInternational journal of clinical and experimental pathology2020
miR-519 inhibits epithelial-mesenchymal transition and biologic behavior of gastric cancer cells by down-regulating FOXQ1.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- The Long Noncoding RNA DUXAP8 Facilitates the Malignant Progression of Colon Cancer via the microRNA-378a-3p/FOXQ1 Axis.Gut and liver · 2025Article
- Advances in the study of FOXQ1: biological functions and mechanisms.Frontiers in oncology · 2025Review
- Emerging role of competing endogenous RNA and associated noncoding RNAs in thyroid cancer.American journal of cancer research · 2022Review
- Reduced miR-519d-3p levels in the synovium and synovial fluid facilitate the progression of post-traumatic osteoarthritis by targeting VEGF.Experimental and therapeutic medicine · 2021Article
- MicroRNAs in Epithelial-Mesenchymal Transition Process of Cancer: Potential Targets for Chemotherapy.International journal of molecular sciences · 2021Review
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, a number of studies have shown that forkhead box Q1 (FOXQ1) plays an important role in the process of epithelial-mesenchymal transition (EMT) of tumors. The aim of this study is to investigate the biologic functions of FOXQ1 and miR-519 in gastric cancer. It was found that FOXQ1 was highly expressed in gastric cancer cells and tumor tissues, and promoted proliferation, migration, invasion, and EMT of gastric cancer cells. miR-519 was weakly expressed in both gastric cancer tissues and gastric cancer cells, up-regulation of miR-519 inhibited the biologic behavior of gastric cancer cells, while down-regulation of miR-519 showed the opposite results. Additionally, miR-519 directly targeted FOXQ1 and inhibited FOXQ1 mRNA and protein expression. Overexpression of FOXQ1 in gastric cancer cells reversed the inhibitory effect of miR-519 on cellular biologic behavior. The results of the present study suggest that the abnormal expression of miR-519 and FOXQ1 may be closely related to gastric cancer development, and miR-519 may play an important role in suppressing tumor related genes in gastric cancer by targeting and regulating FOXQ1.
Indexed as
Identifiers
32269679PMC7137009W3017441656What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.