ArticleInternational journal of clinical and experimental pathology2020
Molecular mechanisms and prognostic markers in head and neck squamous cell carcinoma: a bioinformatic analysis.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- The Emerging Role of Heat Shock Proteins in Nasopharyngeal Carcinoma: A Review.Current medicinal chemistry · 2025Review
- Promising Biomarkers in Head and Neck Cancer: The Most Clinically Important miRNAs.International journal of molecular sciences · 2022Review
- Phytochemicals as Potential Chemopreventive and Chemotherapeutic Agents for Emerging Human Papillomavirus-Driven Head and Neck Cancer: Current Evidence and Future Prospects.Frontiers in pharmacology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the present study was to enhance understanding of the molecular mechanisms underpinning head and neck squamous cell carcinoma (HNSCC). Microarray datasets were obtained from the gene expression omnibus database. By a bioinformatics method, 109 differentially expressed genes were identified between the two mRNA datasets, and these genes were classified primarily into biological process, molecular function, or cellular component. In the protein-protein interaction network analysis, top 20 hub genes were identified, and five (SERPINE1, SERPINH1, SPP1, PLAU and MMP1) of them were associated with the prognosis of HNSCC patients. Immunohistochemistry result also showed that the expression of the proteins encoded by these five genes were significantly upregulated in HNSCC, matching the bioinformatics analysis. Moreover, 28 differentially expressed miRNAs were also identified, with miR-196a and miR-1 being most upregulated and downregulated respectively. Our results provide potential biomarkers for HNSCC and may improve understanding of the molecular mechanisms underlying HNSCC.
Indexed as
Identifiers
32269674PMC7137004W3026237563What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.