Evidence map›Paper›PMID 32269569›Full record

ArticleFrontiers in immunology2020

Leupaxin Expression Is Dispensable for B Cell Immune Responses.

Amélie Bonaud, Simon Clare, Valeria Bisio, John M Sowerby, Shugang Yao, Hanne Ostergaard, Karl Balabanian, Kenneth G C Smith, Marion Espéli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Sec22b is a critical and nonredundant regulator of plasma cell maintenance.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. A genome-wide screen for resilient responses in growing pigs.Genetics, selection, evolution : GSE · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Amélie BonaudInflammation Chemokines and Immunopathology, Institut National de la Santé et de la Recherche Medicale (INSERM), Faculté de Médecine, Université Paris-Sud, Université Paris-Saclay, Clamart, France.
Simon ClareWellcome Trust Genome, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
Valeria BisioUniversité de Paris, Institut de Recherche Saint Louis, EMiLy, Inserm U1160, Paris, France.
John M SowerbyThe Department of Medicine, Cambridge Biomedical, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Shugang YaoDepartment of Medical Microbiology and Immunology, Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada.
Hanne OstergaardDepartment of Medical Microbiology and Immunology, Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada.
Karl BalabanianInflammation Chemokines and Immunopathology, Institut National de la Santé et de la Recherche Medicale (INSERM), Faculté de Médecine, Université Paris-Sud, Université Paris-Saclay, Clamart, France.
Kenneth G C SmithThe Department of Medicine, Cambridge Biomedical, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Marion EspéliInflammation Chemokines and Immunopathology, Institut National de la Santé et de la Recherche Medicale (INSERM), Faculté de Médecine, Université Paris-Sud, Université Paris-Saclay, Clamart, France.
University of London Institute in Paris · FRUniversity of Alberta · CAUniversity of Cambridge · GBWellcome Sanger Institute · GB

Funding

Wellcome TrustWellcome Trust 083650/Z/07/Z
6 · The paper itself

Abstract

The generation of a potent humoral immune response by B cells relies on the integration of signals induced by the B cell receptor, toll-like receptors and both negative and positive co-receptors. Several reports also suggest that integrin signaling plays an important role in this process. How integrin signaling is regulated in B cells is however still partially understood. Integrin activity and function are controlled by several mechanisms including regulation by molecular adaptors of the paxillin family. In B cells, Leupaxin (Lpxn) is the most expressed member of the family and

Indexed as

AnimalsAntibody FormationB-LymphocytesCell Adhesion MoleculesCell DifferentiationCells, CulturedGerminal CenterImmunity, HumoralLymphocyte ActivationMiceMice, KnockoutPlasma CellsReceptors, Antigen, B-CellSignal TransductionTranscription FactorsCell Adhesion MoleculesLpxn protein, mouseReceptors, Antigen, B-CellTranscription FactorsB cellscell activationhumoral immune responseleupaxinplasma cells

Identifiers

PMID32269569
PMCPMC7109257
OpenAlexW3013095844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.