ArticleFrontiers in human neuroscience2020
Establishing a Causal Role for Medial Prefrontal Cortex in Reality Monitoring.
Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- The neural signature of reality-monitoring: A meta-analysis of functional neuroimaging studies.Human brain mapping · 2023Pooled it
- Default Mode Network Modulation by Psychedelics: A Systematic Review.The international journal of neuropsychopharmacology · 2023Pooled it
- A randomised controlled trial investigating the causal role of the medial prefrontal cortex in mediating self-agency during speech monitoring and reality monitoring.Scientific reports · 2024Trial
- Impaired Speaking-Induced Suppression Predicts Degraded Agency and Hallucination Severity in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Predictive processes linking sense of agency and fatigue: a novel allostatic framework.Frontiers in psychology · 2026Article
- Compensatory hallucinogenesis across three neuropsychiatric disorders: a Bayesian account.Brain communications · 2026Review
- Causal role of medial superior frontal cortex on enhancing neural information flow and self-agency judgments in the self-agency network.NeuroImage · 2025Article
- Abnormal resting-state functional connectivity underlies cognitive and clinical symptoms in patients with schizophrenia.Frontiers in human neuroscience · 2023Article
- Folie à Deux in the Setting of COVID-19 Quarantine.Case reports in psychiatry · 2022Article
- Article
- The Role of the Medial Prefontal Cortex in Self-Agency in Schizophrenia.Journal of psychiatry and brain science · 2021Article
- Establishing a Causal Role for Medial Prefrontal Cortex in Reality Monitoring.Frontiers in human neuroscience · 2020Article
- Unraveling the brain mechanisms of source monitoring with non-invasive brain stimulation: A systematic review.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Reality monitoring is defined as the ability to distinguish internally self-generated information from externally-derived information. Functional imaging studies have consistently found that the medial prefrontal cortex (mPFC) is a key brain region subserving reality monitoring. This study aimed to determine a causal role for mPFC in reality monitoring using navigated repetitive transcranial magnetic stimulation (nrTMS). In a subject-blinded sham-controlled crossover design, healthy individuals received either active or sham nrTMS targeting mPFC. Active modulation of mPFC using nrTMS at a frequency of 10 Hz, significantly improved identification of both self-generated and externally-derived information during reality monitoring, when compared to sham or baseline. Targeted excitatory modulation of mPFC also improved positive mood, reduced negative mood, and increased overall alertness/arousal. These results establish optimal nrTMS dosing parameters that maximized tolerability/comfort and induced significant neuromodulatory effects in the mPFC target. Importantly, this is a proof-of-concept study that establishes the mPFC as a novel brain target that can be stimulated with nrTMS to causally impact both higher-order reality monitoring and mood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.