ReviewFrontiers in neuroscience2020
Volatilomes of Bacterial Infections in Humans.
Review in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Volatile Organic Compounds in the Early Diagnosis of Non-healing Surgical Wounds: A Systematic Review.World journal of surgery · 2022Pooled it
- Machine learning elucidates associations between oral microbiota and the decline of sweet taste perception during aging.NPJ science of food · 2026Article
- MXene-coated paper microextraction patch for in vitro metabolic profiling to identify Klebsiella pneumoniae.Mikrochimica acta · 2026Article
- Volatile organic compounds (VOCs) detection for the identification of bacterial infections in clinical wound samples.Talanta · 2025Review
- Profiling of Volatile Metabolites ofInternational journal of molecular sciences · 2025Article
- Cerumenogram as an assay for the metabolic diagnosis of precancer, cancer, and cancer remission.Scientific reports · 2025Article
- The Potential of Fecal Volatile Organic Compound Analysis for the Early Diagnosis of Late-Onset Sepsis in Preterm Infants: A Narrative Review.Sensors (Basel, Switzerland) · 2024Review
- Reduced olfactory performance is associated with changed microbial diversity, oralization, and accumulation of dead biomaterial in the nasal olfactory area.Microbiology spectrum · 2024Article
- Volatilomes of human infection.Analytical and bioanalytical chemistry · 2024Review
- Linking Pedobacter lusitanus NL19 volatile exometabolome with growth medium composition: what can we learn using comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry?Analytical and bioanalytical chemistry · 2023Article
- Volatile Markers for Cancer in Exhaled Breath-Could They Be the Signature of the Gut Microbiota?Molecules (Basel, Switzerland) · 2023Article
- Why Do These Yeasts Smell So Good? Volatile Organic Compounds (VOCs) Produced byMolecules (Basel, Switzerland) · 2023Article
- Current Limitations of Staph Infection Diagnostics, and the Role for VOCs in Achieving Culture-Independent Detection.Pathogens (Basel, Switzerland) · 2023Review
- Gut microbiota functional profiling in autism spectrum disorders: bacterial VOCs and related metabolic pathways acting as disease biomarkers and predictors.Frontiers in microbiology · 2023Article
- Roles of viable but non-culturable state in the survival ofFrontiers in cellular and infection microbiology · 2023Article
- Article
- GC-MS profiling of volatile metabolites produced byFrontiers in molecular biosciences · 2022Article
- Removal of Toxic Volatile Compounds in Batch Culture Prolongs Stationary Phase and Delays Death of Escherichia coli.Applied and environmental microbiology · 2021Article
- Chemical Composition ofMolecules (Basel, Switzerland) · 2021Article
- Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives.Applied microbiology and biotechnology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sense of smell in humans has the capacity to detect certain volatiles from bacterial infections. Our olfactory senses were used in ancient medicine to diagnose diseases in patients. As humans are considered holobionts, each person's unique odor consists of volatile organic compounds (VOCs, volatilome) produced not only by the humans themselves but also by their beneficial and pathogenic micro-habitants. In the past decade it has been well documented that microorganisms (fungi and bacteria) are able to emit a broad range of olfactory active VOCs [summarized in the mVOC database (http://bioinformatics.charite.de/mvoc/)]. During microbial infection, the equilibrium between the human and its microbiome is altered, followed by a change in the volatilome. For several decades, physicians have been trying to utilize these changes in smell composition to develop fast and efficient diagnostic tools, particularly because volatiles detection is non-invasive and non-destructive, which would be a breakthrough in many therapies. Within this review, we discuss bacterial infections including gastrointestinal, respiratory or lung, and blood infections, focusing on the pathogens and their known corresponding volatile biomarkers. Furthermore, we cover the potential role of the human microbiota and their volatilome in certain diseases such as neurodegenerative diseases. We also report on discrete mVOCs that affect humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.