ArticleThe ISME journal2020
Narnaviruses: novel players in fungal-bacterial symbioses.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- Light restores sporulation in Rhizopus microsporus cured of its endosymbionts, unveiling their role in fitness and virulence.The ISME journal · 2026Article
- Lineage-specific endosymbiosis in Mucorales: restriction ofCurrent research in microbial sciences · 2026Article
- Endosymbiotic interactions in the fungal kingdom: a framework for progressive endosymbiosis.Frontiers in microbiology · 2026Review
- Exploring the impact of a chemical disinfectant and an antiviral drug for RNA virus management in the Mediterranean fruit fly mass-rearing.Insect science · 2025Article
- High-Throughput Sequencing Reveals the Mycoviral Diversity of the Pathogenic Grape FungusViruses · 2025Article
- Integrating Sequence- and Structure-Based Similarity Metrics for the Demarcation of Multiple Viral Taxonomic Levels.Viruses · 2025Article
- Endofungal bacteria as hidden facilitators of biotic interactions.The ISME journal · 2025Review
- New lineages of RNA viruses from clinical isolates ofmSphere · 2024Article
- Co-infection of Four Novel Mycoviruses from Three Lineages Confers Hypovirulence on Phytopathogenic Fungus Ustilaginoidea virens.Rice (New York, N.Y.) · 2024Article
- Covert RNA viruses in medflies differ in their mode of transmission and tissue tropism.Journal of virology · 2024Article
- Fungal holobionts as blueprints for synthetic endosymbiotic systems.PLoS biology · 2024Article
- New clades of viruses infecting the obligatory biotrophVirus evolution · 2024Article
- A parasite odyssey: An RNA virus concealed inVirus evolution · 2024Article
- Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned?Microorganisms · 2023Review
- Scientific novelty beyond the experiment.Microbial biotechnology · 2023Article
- Divergent Evolution of Early Terrestrial Fungi Reveals the Evolution of Mucormycosis Pathogenicity Factors.Genome biology and evolution · 2023Article
- The virome of the invasive Asian bush mosquitoVirus evolution · 2023Article
- Human Clinical Isolates of Pathogenic Fungi Are Host to Diverse Mycoviruses.Microbiology spectrum · 2022Article
- A highly conserved gene locus in endofungal bacteria codes for the biosynthesis of symbiosis-specific cyclopeptides.PNAS nexus · 2022Article
- Killing the competition: a theoretical framework for liver-stage malaria.Open biology · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhizopus microsporus is an early-diverging fungal species with importance in ecology, agriculture, food production, and public health. Pathogenic strains of R. microsporus harbor an intracellular bacterial symbiont, Mycetohabitans (formerly named Burkholderia). This vertically transmitted bacterial symbiont is responsible for the production of toxins crucial to the pathogenicity of Rhizopus and remarkably also for fungal reproduction. Here we show that R. microsporus can live not only in symbiosis with bacteria but also with two viral members of the genus Narnavirus. Our experiments revealed that both viruses replicated similarly in the growth conditions we tested. Viral copies were affected by the developmental stage of the fungus, the substrate, and the presence or absence of Mycetohabitans. Absolute quantification of narnaviruses in isolated asexual sporangiospores and sexual zygospores indicates their vertical transmission. By curing R. microsporus of its viral and bacterial symbionts and reinfecting bacteria to reestablish symbiosis, we demonstrate that these viruses affect fungal biology. Narnaviruses decrease asexual reproduction, but together with Mycetohabitans, are required for sexual reproductive success. This fungal-bacterial-viral system represents an outstanding model to investigate three-way microbial symbioses and their evolution.
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