ArticleScientific reports2020
Homeobox proteins are essential for fungal differentiation and secondary metabolism in Aspergillus nidulans.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Functional characterization of HMG_9 and CMicrobial cell factories · 2026Article
- Exploring the Critical Environmental Optima and Biotechnological Prospects of Fungal Fruiting Bodies.Microbial biotechnology · 2025Review
- Engineering of Global Transcriptional Regulators (GTRs) inJournal of fungi (Basel, Switzerland) · 2025Review
- The transcription factor PITX1 cooperates with super-enhancers to regulate the expression of DUSP4 and inhibit pyroptosis in pulmonary artery smooth muscle cells.Respiratory research · 2025Article
- Homeobox transcription factor BmHox7 is required for sexual reproduction, but not for appressorial development and pathogenicity inMycoscience · 2025Article
- Identification of Homeobox Transcription Factors in a Dimorphic FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Expanded Gene Regulatory Network Reveals Potential Light-Responsive Transcription Factors and Target Genes inInternational journal of molecular sciences · 2024Article
- Genome-Wide Identification and Characterization of Homeobox Transcription Factors inInternational journal of molecular sciences · 2024Article
- Sterigmatocystin induces autophagic and apoptotic cell death of liver cancer cells via downregulation of XIAP.Heliyon · 2024Article
- Regulatory functions of homeobox domain transcription factors in fungi.Applied and environmental microbiology · 2024Review
- The Forkhead GeneJournal of microbiology and biotechnology · 2023Article
- Regulators of the Asexual Life Cycle ofCells · 2023Review
- Molecular regulation of fungal secondary metabolism.World journal of microbiology & biotechnology · 2023Review
- Homeobox transcription factor HbxA influences expression of over one thousand genes in the model fungus Aspergillus nidulans.PloS one · 2023Article
- Comparative transcriptome and WGCNA reveal key genes involved in lignocellulose degradation in Sarcomyxa edulis.Scientific reports · 2022Article
- Transcription Factors in the FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Pitx genes in development and disease.Cellular and molecular life sciences : CMLS · 2021Review
- HbxB Is a Key Regulator for Stress Response and β-Glucan Biogenesis inMicroorganisms · 2021Article
- Homeotic Genes: Clustering, Modularity, and Diversity.Frontiers in cell and developmental biology · 2021Review
- Unveiling the Functions of the VosA-VelB Target GeneMycobiology · 2021Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The homeobox domain-containing transcription factors play an important role in the growth, development, and secondary metabolism in fungi and other eukaryotes. In this study, we characterized the roles of the genes coding for homeobox-type proteins in the model organism Aspergillus nidulans. To examine their roles in A. nidulans, the deletion mutant strains for each gene coding for homeobox-type protein were generated, and their phenotypes were examined. Phenotypic analyses revealed that two homeobox proteins, HbxA and HbxB, were required for conidia production. Deletion of hbxA caused abnormal conidiophore production, decreased the number of conidia in both light and dark conditions, and decreased the size of cleistothecia structures. Overexpressing hbxA enhanced the production of asexual spores and formation of conidiophore under the liquid submerged conditions. The hbxB deletion mutant strains exhibited decreased asexual spore production but increased cleistothecia production. The absence of hbxB decreased the trehalose content in asexual spores and increased their sensitivity against thermal and oxidative stresses. The ΔhbxA strains produced more sterigmatocystin, which was decreased in the ΔhbxB strain. Overall, our results show that HbxA and HbxB play crucial roles in the differentiation and secondary metabolism of the fungus A. nidulans.
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