ArticleNature communications2020
Spatiotemporal refinement of signal flow through association cortex during learning.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Real-time closed-loop feedback system for mouse mesoscale cortical signal and movement control.eLife · 2026Article
- Learning induces activation-mechanism-dependent neural plasticity in an intracortical microstimulation task.Science advances · 2026Article
- A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.bioRxiv : the preprint server for biology · 2026Article
- Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Perirhinal input to auditory cortex supports memory-guided sensory perception.Science advances · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
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- Distinct roles of cortical layer 5 subtypes in associative learning.Nature communications · 2026Article
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- Somatosensory control of thalamic relay neurons is regulated by two distinct layer 6 feedback systems.iScience · 2026Article
- Pan-cortical cellular imaging in freely behaving mice using a miniaturized micro-camera array microscope (mini-MCAM).Science advances · 2025Article
- Coordinated multi-level adaptations across neocortical areas during task learning.Nature communications · 2025Article
- Learning, prediction accuracy, and neural plasticity in sensory cortex.Current opinion in neurobiology · 2025Review
- Striatal arbitration between choice strategies guides few-shot adaptation.Nature communications · 2025Article
- Amygdala and Cortex Relationships during Learning of a Sensory Discrimination Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A transthalamic pathway crucial for perception.Nature communications · 2024Article
- Wide-field imaging in behaving mice as a tool to study cognitive function.Neurophotonics · 2024Review
- Special Section Guest Editorial: Open-source neurophotonic tools for neuroscience.Neurophotonics · 2024Article
- Transient enhancement of stimulus-evoked activity in neocortex during sensory learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Association areas in neocortex encode novel stimulus-outcome relationships, but the principles of their engagement during task learning remain elusive. Using chronic wide-field calcium imaging, we reveal two phases of spatiotemporal refinement of layer 2/3 cortical activity in mice learning whisker-based texture discrimination in the dark. Even before mice reach learning threshold, association cortex-including rostro-lateral (RL), posteromedial (PM), and retrosplenial dorsal (RD) areas-is generally suppressed early during trials (between auditory start cue and whisker-texture touch). As learning proceeds, a spatiotemporal activation sequence builds up, spreading from auditory areas to RL immediately before texture touch (whereas PM and RD remain suppressed) and continuing into barrel cortex, which eventually efficiently discriminates between textures. Additional correlation analysis substantiates this diverging learning-related refinement within association cortex. Our results indicate that a pre-learning phase of general suppression in association cortex precedes a learning-related phase of task-specific signal flow enhancement.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.