ArticleJournal of atherosclerosis and thrombosis2021
A Combination of Blood Pressure and Total Cholesterol Increases the Lifetime Risk of Coronary Heart Disease Mortality: EPOCH-JAPAN.
Article in Journal of atherosclerosis and thrombosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Development and Validation of an Explainable Prediction Model to Assess the Risk of Coronary Artery Disease in Young and Middle-Aged Individuals.Reviews in cardiovascular medicine · 2025Article
- Long-term risk of cardiovascular mortality according to age group and blood pressure categories of the latest guideline.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Cross-sectional study on the association between serum uric acid levels and non-alcoholic fatty liver disease in an elderly population.Scientific reports · 2025Article
- The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease.Journal of inflammation research · 2025Article
- Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022.Journal of atherosclerosis and thrombosis · 2024Article
- Impact of medical checkup parameters on major adverse cardiovascular events in the general Japanese population.Preventive medicine reports · 2024Article
- A multivariate joint model to adjust for random measurement error while handling skewness and correlation in dietary data in an epidemiologic study of mortality.Annals of epidemiology · 2023Article
- Association between Indoor Temperature in Winter and Serum Cholesterol: A Cross-Sectional Analysis of the Smart Wellness Housing Survey in Japan.Journal of atherosclerosis and thrombosis · 2022Article
- Predictors of Carotid Atherosclerosis Progression: Evidence from an Ultrasonography Laboratory.Brain sciences · 2022Article
- The Effects of Capsinoids and Fermented Red Pepper Paste Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Clinical nutrition research · 2022Article
- Impact of Major Cardiovascular Risk Factors on the Incidence of Cardiovascular Disease among Overweight and Non-Overweight Individuals: The Circulatory Risk in Communities Study (CIRCS).Journal of atherosclerosis and thrombosis · 2022Article
- The difference of lipid profiles between psoriasis with arthritis and psoriasis without arthritis and sex-specific downregulation of methotrexate on the apolipoprotein B/apolipoprotein A-1 ratio.Arthritis research & therapy · 2022Article
- Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population.Journal of the American Heart Association · 2021Article
- Lifetime Risk of Coronary Heart Disease in Japan.Journal of atherosclerosis and thrombosis · 2021Article
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Authors and funding
20 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimLifetime risk (LTR) indicates the absolute risk of disease during the remainder of an individual's lifetime. We aimed to assess the LTRs for coronary heart disease (CHD) mortality associated with blood pressure (BP) and total cholesterol levels in an Asian population using a meta-analysis of individual participant data because no previous studies have assessed this risk.
methodsWe analyzed data from 105,432 Japanese participants in 13 cohorts. Apart from grade 1 and 2-3 hypertension groups, we defined "normal BP" as systolic/diastolic BP ＜130/＜80 mmHg and "high BP" as 130-139/80-89 mmHg. The sex-specific LTR was estimated while considering the competing risk of death.
resultsDuring the mean follow-up period of 15 years (1,553,735 person-years), 889 CHD deaths were recorded. The 10-year risk of CHD mortality at index age 35 years was ≤ 0.11%, but the corresponding LTR was ≥ 1.84%. The LTR of CHD at index age 35 years steeply increased with an increase in BP of participants with high total cholesterol levels [≥ 5.7 mmol/L (220 mg/dL)]. This risk was 7.73%/5.77% (95% confidence interval: 3.53%-10.28%/3.83%-7.25%) in men/women with grade 2-3 hypertension and high total cholesterol levels. In normal and high BP groups, the absolute differences in LTRs between the low and high total cholesterol groups were ≤ 0.25% in men and ≤ 0.40% in women.
conclusionsHigh total cholesterol levels contributed to an elevated LTR of CHD mortality in hypertensive individuals. These findings could help guide high-risk young individuals toward initiating lifestyle changes or treatments.
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