Evidence map›Paper›PMID 32269192›Full record

ArticleInternal medicine (Tokyo, Japan)2020

Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis.

Kei Tomiyoshi, Hiroki Sato, Kentaro Tominaga, Yuzo Kawata, Daisuke Okamoto, Yoichi Kakuta, Junji Yokoyama, Shuji Terai

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Case report:Frontiers in pharmacology · 2023
    Article
  4. Importance ofJournal of personalized medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kei TomiyoshiDivision of Gastroenterology, Niigata University Medical and Dental Hospital, Japan.
Hiroki SatoDivision of Gastroenterology, Niigata University Medical and Dental Hospital, Japan.
Kentaro TominagaDivision of Gastroenterology, Niigata University Medical and Dental Hospital, Japan.
Yuzo KawataDivision of Gastroenterology, Niigata University Medical and Dental Hospital, Japan.
Daisuke OkamotoDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.
Yoichi KakutaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.
Junji YokoyamaDivision of Gastroenterology, Niigata University Medical and Dental Hospital, Japan.
Shuji TeraiDivision of Gastroenterology, Niigata University Medical and Dental Hospital, Japan.
Niigata University Medical and Dental Hospital · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiopurine drugs are commonly used to treat immunologic diseases. However, the narrow therapeutic safety margin demands evidence-based precision medicine approaches. NUDT15 variants are associated with thiopurine-induced adverse events, particularly in Asians. We herein report a rare genotype of His/His in NUDT15 codon 139 in a case of ulcerative colitis and review the relevant literature. The patient experienced severe thiopurine-associated adverse events, including leukopenia and alopecia. There is no literature on the His/His genotype in NUDT15 codon 139, and our case suggests cautious use or the contraindication of thiopurines for patients with this genotype.

Indexed as

AlopeciaAsian PeopleAzathioprineCodonColitis, UlcerativeGenetic Predisposition to DiseaseGenotypeHumansLeukopeniaNudix HydrolasesPyrophosphatasesRisk FactorsAzathioprineCodonNudix HydrolasesNUDT15 protein, humanPyrophosphatasesHis/His genotypeinflammatory bowel diseaseleukopeniaNUDT15thiopurineulcerative colitis

Identifiers

PMID32269192
PMCPMC7402964
OpenAlexW3015769721

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.