Evidence map›Paper›PMID 32269135›Full record

ArticlePediatrics2020

Network Implementation of Guideline for Early Detection Decreases Age at Cerebral Palsy Diagnosis.

Nathalie L Maitre, Vera J Burton, Andrea F Duncan, Sai Iyer, Betsy Ostrander, Sarah Winter, Lauren Ayala, Stephanie Burkhardt, Gwendolyn Gerner, Ruth Getachew and 7 more

Open access · greenAbstract read
In one paragraph

Article in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 112 citations in OpenAlex.

  1. Trial
  2. Standardizing early cerebral palsy detection in high-risk infants: reducing age at diagnosis through a quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2026
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  16. Social Determinants of Health in Cerebral Palsy.Journal of clinical medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Nathalie L MaitreCenter for Perinatal Research and nathalie.maitre@nationwidechildrens.org.
Vera J BurtonDivision of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland.
Andrea F DuncanDepartment of Pediatrics, The University of Texas Health Science Center at Houston, Houston, Texas.
Sai IyerProgram of Developmental Behavioral Pediatrics, Department of Pediatrics, Mattel Children's Hospital, and University of California, Los Angeles, Los Angeles, California.
Betsy OstranderDepartment of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah; and.
Sarah WinterDepartment of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah; and.
Lauren AyalaDepartment of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah; and.
Stephanie BurkhardtCenter for Perinatal Research and.
Gwendolyn GernerDivision of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland.
Ruth GetachewDivision of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland.
Kelsey JiangProgram of Developmental Behavioral Pediatrics, Department of Pediatrics, Mattel Children's Hospital, and University of California, Los Angeles, Los Angeles, California.
Laurie LesherDepartment of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah; and.
Carrie M PerezDepartment of Pediatrics, The University of Texas Health Science Center at Houston, Houston, Texas.
Melissa Moore-ClingenpeelBiostatistics Core, The Abigail Wexner Research Institute, and.
Rebecca LamCerebral Palsy Foundation, New York, New York.
Dennis J LewandowskiCenter for Perinatal Research and.
Rachel ByrneCerebral Palsy Foundation, New York, New York.
University of Utah · USKennedy Krieger Institute · USPerinatal Institute · GBThe University of Texas Health Science Center at Houston · USUnited Cerebral Palsy · USNationwide Children's Hospital · US

Funding

Early Childhood Constraint Therapy for Sensory/Motor Impairment in Cerebral PalsyR01HD081120 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI MAITRE, NATHALIE · 2015 to 2025
$5.9M
NICHD NIH HHS R01 HD081120
6 · The paper itself

Abstract

BACKGROUND AND

objectivesEarly diagnosis of cerebral palsy (CP) is critical in obtaining evidence-based interventions when plasticity is greatest. In 2017, international guidelines for early detection of CP were published on the basis of a systematic review of evidence. Our study aim was to reduce the age at CP diagnosis throughout a network of 5 diverse US high-risk infant follow-up programs through consistent implementation of these guidelines.

methodsThe study leveraged plan-do-study-act and Lean methodologies. The primary outcome was age at CP diagnosis. Data were acquired during the corresponding 9-month baseline and quarterly throughout study. Balancing measures were clinic no-show rates and parent perception of the diagnosis visit. Clinic teams conducted strengths, weaknesses, opportunities, and threats analyses, process flow evaluations, standardized assessments training, and parent questionnaires. Performance of a 3- to 4-month clinic visit was a critical process step because it included a Hammersmith Infant Neurologic Examination, a General Movements Assessment, and standardized assessments of motor function.

resultsThe age at CP diagnosis decreased from a weighted average of 19.5 (95% confidence interval 16.2 to 22.8) to 9.5 months (95% confidence interval 4.5 to 14.6), with

conclusionsLarge-scale implementation of international guidelines for early detection of CP is feasible in diverse high-risk infant follow-up clinics. The initiative was received positively by families and without adversely affecting clinic operational flow. Additional parent support and education are necessary.

Indexed as

Age FactorsCerebral PalsyCommunity NetworksEarly DiagnosisFemaleHumansInfantMaleNeurologic ExaminationPractice Guidelines as TopicQuality Improvement

Identifiers

PMID32269135
PMCPMC7193973
OpenAlexW3015359987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.