Evidence map›Paper›PMID 32269129›Full record

ArticleJournal of virology2020

Deep Sequencing Reveals Compartmentalized HIV-1 in the Semen of Men with and without Sexually Transmitted Infection-Associated Urethritis.

Olivia D Council, Shuntai Zhou, Chase D McCann, Irving Hoffman, Gerald Tegha, Deborah Kamwendo, Mitch Matoga, Sergei L Kosakovsky Pond, Myron S Cohen, Ronald Swanstrom

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Effects of Urethritis on Human Immunodeficiency Virus (HIV) in Semen: Implications for HIV Prevention and Cure.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Olivia D CouncilLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Shuntai ZhouLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-8353-386X
Chase D McCannDepartment of Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, New York, USA.
Irving HoffmanDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Gerald TeghaUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Deborah KamwendoUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Mitch MatogaUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Sergei L Kosakovsky PondDepartment of Biology, Temple University, Philadelphia, Pennsylvania, USA.
Myron S CohenDivision of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ronald SwanstromLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA ron_swanstrom@med.unc.edu.
University of North Carolina at Chapel Hill · USUniversity of Malawi · MW

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Training in Sexually Transmitted Infections and HIVT32AI007001 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SENA-SOBERANO, ARLENE C. · 1985 to 2025
$10.9M
Turning big data analysis infrastructure for HIV researchR01AI134384 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI NEKRUTENKO, ANTON, POND, SERGEI L KOSAKOVSKY · 2017 to 2021
$4.2M
HIV Evolution Defines Virus-Host/Drug Interactions In Viremic and Aviremic PeopleR01AI140970 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ronald I Swanstrom, Shuntai Zhou · 2018 to 2026
$4.1M
The Compartmental Biology of HIV in the Male Genital TractR01DK108424 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COHEN, MYRON SCOTT · 2015 to 2019
$3.0M
HyPhy: Molecular Evolutionary AnalysesR01GM093939 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI MUSE, SPENCER V., POND, SERGEI L KOSAKOVSKY · 2010 to 2018
$2.5M
NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI134384NIAID NIH HHS R01 AI140970NIAID NIH HHS T32 AI007001NIDDK NIH HHS R01 DK108424NIGMS NIH HHS R01 GM093939
6 · The paper itself

Abstract

Concurrent sexually transmitted infections (STI) can increase the probability of HIV-1 transmission primarily by increasing the viral load present in semen. In this study, we explored the relationship of HIV-1 in blood and seminal plasma in the presence and absence of urethritis and after treatment of the concurrent STI. Primer ID deep sequencing of the V1/V3 region of the HIV-1

Indexed as

AdultBase SequenceCD4 Lymphocyte CountCD4-Positive T-LymphocytesCohort StudiesCytokinesenv Gene Products, Human Immunodeficiency VirusHigh-Throughput Nucleotide SequencingHIV-1HIV InfectionsHumansMalawiMaleMiddle AgedPhylogenySemenCytokinesenv Gene Products, Human Immunodeficiency Viruscompartmentalizationgenital tractHIV-1phylogenyviral diversity

Identifiers

PMID32269129
PMCPMC7307086
OpenAlexW3015384049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.