Evidence map›Paper›PMID 32269126›Full record

ArticleJournal of virology2020

KDM6A-Mediated Expression of the Long Noncoding RNA DINO Causes TP53 Tumor Suppressor Stabilization in Human Papillomavirus 16 E7-Expressing Cells.

Surendra Sharma, Karl Munger

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Long non-coding RNAJournal of thoracic disease · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Surendra SharmaBiochemistry Program, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA.
Karl MungerBiochemistry Program, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA karl.munger@tufts.edu.
Tufts University · US

Funding

BIOLOGICAL ACTIVITY OF HPV E7 IN HUMAN EPITHELIAL CELLSR01CA066980 · NCI · TUFTS UNIVERSITY BOSTON · PI MUNGER, KARL · 1996 to 2019
$7.4M
Mouse Model of Human Papillomavirus PathogenesisR01CA228543 · NCI · TUFTS UNIVERSITY BOSTON · PI LAMBERT, PAUL F., MUNGER, KARL · 2019 to 2023
$2.3M
Regulation of human papillomavirus pathogenesis by long non-coding RNAsR21AI147176 · NIAID · TUFTS UNIVERSITY BOSTON · PI MUNGER, KARL · 2019 to 2020
$446k
NCI NIH HHS R01 CA066980NCI NIH HHS R01 CA228543NIAID NIH HHS R21 AI147176
6 · The paper itself

Abstract

Human papillomavirus 16 (HPV16) E7 has long been known to stabilize the tumor suppressor TP53. However, the molecular mechanism of TP53 stabilization by HPV16 E7 has remained obscure, and this stabilization can occur independently of the E2F-regulated MDM2 inhibitor p14

Indexed as

Antibiotics, AntineoplasticCell SurvivalCyclin-Dependent Kinase Inhibitor p21DoxorubicinE2F1 Transcription FactorGene Expression RegulationHistone DemethylasesHost-Pathogen InteractionsHuman papillomavirus 16HumansHypoglycemic AgentsKeratinocytesMetforminPapillomavirus E7 ProteinsPrimary Cell CultureProtein StabilityAntibiotics, AntineoplasticCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21DINOL lncRNA, humanDoxorubicinE2F1 protein, humanE2F1 Transcription FactorHistone DemethylasesHypoglycemic AgentsKDM6A protein, humanMetforminMYC protein, humanoncogene protein E7, Human papillomavirus type 16Papillomavirus E7 ProteinsProto-Oncogene Proteins c-mycRB1 protein, humanRetinoblastoma Binding ProteinsRNA, Long NoncodingRNA, Small InterferingTP53 protein, humanTumor Suppressor Protein p53Ubiquitin-Protein LigaseschemotherapyDINODINOLDNA damageE7human papillomavirusKDM6AlncRNAlong noncoding RNAmetabolismmetforminTP53

Identifiers

PMID32269126
PMCPMC7307095
OpenAlexW3015940738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.