ArticleCancer research2020
Hispanic/Latino Patients with Gastric Adenocarcinoma Have Distinct Molecular Profiles Including a High Rate of Germline
Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges.Molecular oncology · 2021Pooled it
- PD-L1 expression in gastric cancer assessed with antibodies 28-8 and 22C3.Scientific reports · 2025Observational
- Actionable Genes and Carcinogenic Pathways for Gastric Cancer in Latinos.Cancer medicine · 2025Article
- Retrospective analysis of Claudin18.2 expression in ethnically diverse patients with gastroesophageal adenocarcinoma.Journal of gastrointestinal oncology · 2025Article
- Deep Gaussian process with uncertainty estimation for microsatellite instability and immunotherapy response prediction from histology.NPJ digital medicine · 2025Article
- Pathogenic germline variants in mismatch repair genes in patients with microsatellite instability-high gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Exploring Socio-Behavioral Correlates of Metabolic and Inflammatory Risk in a University Sample Residing Along the U.S./Mexico Border: A Pilot Study Concomitantly Collecting Survey Data, Blood and Hair Samples, and Physical Measures.International journal of environmental research and public health · 2025Article
- Factors Associated With Minority Patient Enrollment in a Gastric Cancer Biobank.The Journal of surgical research · 2025Article
- Hispanic/Latino Ethnicity Is an Independent Predictor of Worse Survival for Gastric Cancer in a Multicenter Safety-Net Patient Population.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming.The Journal of experimental medicine · 2024Article
- Incidence trends of gastric cancer in the United States over 2000-2020: A population-based analysis.PloS one · 2024Article
- CDH1 loss promotes diffuse-type gastric cancer tumorigenesis via epigenetic reprogramming and immune evasion.bioRxiv : the preprint server for biology · 2023Article
- Ethnic Disparities in Early-Onset Gastric Cancer Persist across Rural-Urban Geographies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- ASO Author Reflections: Nativity Status of Hispanic Gastric Cancer Patients is Associated with Survival.Annals of surgical oncology · 2022Article
- Multiregional Sequencing Analysis Reveals Extensive Genetic Heterogeneity in Gastric Tumors from Latinos.Cancer research communications · 2022Article
- Somatic Mutational Landscape in Mexican Patients:International journal of molecular sciences · 2022Article
- Colorectal Cancer Survivors' Receptivity toward Genomic Testing and Targeted Use of Non-Steroidal Anti-Inflammatory Drugs to Prevent Cancer Recurrence.Journal of community genetics · 2022Article
- Gaps in Providers' Knowledge Delays Gastric Cancer Diagnosis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Lenvatinib inhibits the growth of gastric cancer patient-derived xenografts generated from a heterogeneous population.Journal of translational medicine · 2022Article
- The presentation of Hispanic gastric cancer patients varies by location of patient ancestry.Journal of surgical oncology · 2021Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Hispanic/Latino patients have a higher incidence of gastric cancer and worse cancer-related outcomes compared with patients of other backgrounds. Whether there is a molecular basis for these disparities is unknown, as very few Hispanic/Latino patients have been included in previous studies. To determine the genomic landscape of gastric cancer in Hispanic/Latino patients, we performed whole-exome sequencing (WES) and RNA sequencing on tumor samples from 57 patients; germline analysis was conducted on 83 patients. The results were compared with data from Asian and White patients published by The Cancer Genome Atlas. Hispanic/Latino patients had a significantly larger proportion of genomically stable subtype tumors compared with Asian and White patients (65% vs. 21% vs. 20%,
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