ArticleThe Journal of arthroplasty2020
Postoperative Serum Cytokine Levels Are Associated With Early Stiffness After Total Knee Arthroplasty: A Prospective Cohort Study.
Article in The Journal of arthroplasty, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Indicators and medical tests to identify lower limb swelling causes after total knee arthroplasty: a Delphi study with multidisciplinary experts.Journal of orthopaedic surgery and research · 2023Pooled it
- Treatment of arthrofibrosis and stiffness after total knee arthroplasty: an updated review of the literature.International orthopaedics · 2022Pooled it
- Arthrofibrosis After Total Knee Arthroplasty: Biological Mechanisms, Diagnosis, and Treatment: An International Consensus Symposium.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2026Article
- Angiotensin II receptor blockers and their applications in orthopaedic surgery and musculoskeletal medicine.Annals of joint · 2024Review
- Evidence for an association of serum microanalytes and myofascial pain syndrome.BMC musculoskeletal disorders · 2023Article
- Biochemical markers of postsurgical knee arthrofibrosis: A systematic review.Journal of orthopaedics · 2023Review
- Association of circulating gene expression signatures with stiffness following total knee arthroplasty for osteoarthritis: a pilot study.Scientific reports · 2022Article
- Differences in synovial fibrosis relative to range of motion in knee osteoarthritis patients.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Articular cartilage and synovium may be important sources of post-surgical synovial fluid inflammatory mediators.American journal of translational research · 2022Article
- Cross-Communication Between Knee Osteoarthritis and Fibrosis: Molecular Pathways and Key Molecules.Open access journal of sports medicine · 2022Review
- Comparison of intra-articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty.Journal of orthopaedic surgery and research · 2021Article
- Reply to Letter to the Editor on 'Postoperative Serum Cytokine Levels Are Associated With Early Stiffness After Total Knee Arthroplasty: A Prospective Cohort Study".The Journal of arthroplasty · 2021Article
- Quantification of intra-articular fibrosis in patients with stiff knee arthroplasties using metal-reduction MRI.The bone & joint journal · 2020Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInflammatory cytokines have been implicated in organ fibrosis; however, their role in the development of arthrofibrosis after total knee arthroplasty (TKA) has not been well explored. The purpose of this study is to assess whether perioperative synovial fluid or blood plasma cytokine levels are associated with reduced early post-TKA range of motion.
methodsA total of 179 patients with end-stage idiopathic osteoarthritis undergoing TKA were enrolled in this prospective cohort study. Synovial fluid and blood plasma were collected prearthrotomy and plasma was collected longitudinally in the postacute care unit and on postoperative days (PODs) 1 and 2. Stiffness was defined as ≤95° range of motion measured with a goniometer at 6 weeks (±2 weeks).
resultsThirty-two of 162 (19.8%) patients analyzed were stiff at 6 weeks postoperatively. Postoperative plasma levels of 9 cytokines (Eotaxin3, IL-5, IL12_23p40, IP10, VEGF, IL-7, IL-12p70, IL-16, IL-17a) were significantly different between stiff and nonstiff patients on POD1 and/or POD2. An association between preoperative plasma and synovial fluid cytokine levels and the development of postoperative stiffness was not detected.
conclusionThe results of this study suggest that there is a distinct acute postoperative cytokine response profile in patients who develop stiffness 6 weeks after TKA. This profile was characterized by significant differences in levels of 9 cytokines over the first 2 postoperative days. These results identify cytokines that are potential biomarkers for risk of early stiffness after TKA and may play a role in the pathophysiology of this outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.