Evidence map›Paper›PMID 32268923›Full record

ArticleSystematic reviews2020

Traditional Chinese herbal medicine for treating novel coronavirus (COVID-19) pneumonia: protocol for a systematic review and meta-analysis.

Yuxi Li, Xiaobo Liu, Liuxue Guo, Juan Li, Dongling Zhong, Yonggang Zhang, Mike Clarke, Rongjiang Jin

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Systematic reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04501965 phase2unknown statusnot on this map

Evaluation de l'efficacité et de la tolérance de Quinquina et d'un phytomédicament " ACAR " en Comparaison Avec l'Hydroxychloroquine Chez Des Adultes Malades de Covid-19 Sans symptômes

TypeinterventionalSponsorInstitute for Research and Development of Medicinal and Food Plants of GuineaRan2020 to 2020Enrolled231ConditionsCovid19ArmsHydroxychloroquine/Azithromycine, Quinquina-Stevia/Azythromycin, 4Plants/Azythromycin
NCT04502342 phase2unknown statusnot on this map

Évaluationefficacité et tolérance d'Une médication à Base de Cosphérunate et d'un phytomédicament Antiviral Par Voie Orale en Comparaison Avec un Traitement à Base d'Hydroxychloroquine Chez Des Adultes Malades Covid-19 Sans Complications

TypeinterventionalSponsorInstitute for Research and Development of Medicinal and Food Plants of GuineaRan2020 to 2020Enrolled30ConditionsCovid19ArmsHydroxycloroquine and Azythromycine, Cospherunate/Azythromycine, Cospherunate/Phytomedicine/Azythromycien
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. The add-on effect of Chinese herbal medicine on COVID-19: A systematic review and meta-analysis.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yuxi LiSchool of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xiaobo LiuSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Liuxue GuoHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Juan LiSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Dongling ZhongSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yonggang ZhangWest China Hospital, Sichuan University, Chengdu, China.
Mike ClarkeNorthern Ireland Clinical Trials Unit and Methodology Hub, Centre for Public Health, Queen's University Belfast, Belfast, UK. m.clarke@qub.ac.uk.
Rongjiang JinSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China. cdzyydxjrj@126.com.
Chengdu University of Traditional Chinese Medicine · CNQueen's University Belfast · GBWest China Hospital of Sichuan University · CN

Funding

Medical Research Council G0901530
6 · The paper itself

Abstract

backgroundA new type of coronavirus, novel coronavirus (COVID-19), is causing an increasing number of cases of pneumonia and was declared a Public Health Emergency of International Concern by the World Health Organization on 30 January 2020. The virus first appeared in Wuhan, China, in late December 2019, and traditional Chinese herbal medicine is being used for its treatment. This systematic review and meta-analysis will assess studies of the effects of traditional Chinese herbal medicine in COVID-19 pneumonia.

methodsWe will search electronic databases including PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), and Wanfang database using keywords related to COVID-19 and traditional Chinese herbal medicine. Reference lists of relevant trials and reviews will be searched. We will manually search gray literature, such as conference proceedings and academic degree dissertations, and trial registries. Two independent reviewers will screen studies (XL and DZ), extract data (YL and LG), and evaluate risk of bias (YL and DZ). Data analysis will be conducted using the Review Manager software (version 5.3.5) and R software (version 3.6.1). Statistical heterogeneity will be assessed using a standard chi-square test with a significance level of P < 0.10. Biases associated with study size (e.g., publication bias) will be investigated using funnel plots, Egger's test and Begg's test, and Trim and Fill analysis. DISCUSSION: This study will provide a high-quality synthesis of the effects of traditional Chinese herbal medicine for COVID-19. The use of traditional Chinese herbal medicine for treatment or prevention of these novel viral infections affecting the pneumonia will be investigated. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration number: CRD42020168004.

Indexed as

Medicine, Chinese TraditionalBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentDrugs, Chinese HerbalHumansMeta-Analysis as TopicPandemicsPneumonia, ViralSARS-CoV-2Systematic Reviews as TopicDrugs, Chinese HerbalCoronavirusCOVID-19Meta-analysisPneumoniaSystematic reviewTraditional Chinese herbal medicine emerging infectious diseases

Identifiers

PMID32268923
PMCPMC7138957
OpenAlexW3016089766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.