Evidence map›Paper›PMID 32268918›Full record

ArticleMalaria journal2020

Assessment of platelet indices and platelet activation markers in children with Plasmodium falciparum malaria.

Renate Asare, Clement Opoku-Okrah, Kwabena Owusu Danquah, Ohene Opare-Sem, Otchere Addai-Mensah, Daniel Gyamfi, Francis Agyei Amponsah, Edward Y Afriyie, Richard Vikpebah Duneeh, David Ntiamoah Ofosu and 1 more

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In one paragraph

Article in Malaria journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Blood Platelets as an Important but Underrated Circulating Source of TGFβ.International journal of molecular sciences · 2021
    Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Renate AsareHeamatology Unit, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana. Renateasare1@gmail.com.
Clement Opoku-OkrahDepartment of Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Kwabena Owusu DanquahDepartment of Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Ohene Opare-SemHeamatology Unit, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana.
Otchere Addai-MensahDepartment of Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Daniel GyamfiDepartment of Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Francis Agyei AmponsahSt. John of God Hospital, Sunyani, Ghana.
Edward Y AfriyieHeamatology Unit, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana.
Richard Vikpebah DuneehHeamatology Unit, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana.
David Ntiamoah OfosuDepartment of Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Michael FrimpongKumasi Center for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Kwame Nkrumah University of Science and Technology · GHKomfo Anokye Teaching Hospital · GHKumasi Centre for Collaborative Research in Tropical Medicine · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlasmodium falciparum malaria remains one of the world's major infectious diseases that cause most morbidity and mortality, particularly in children. In Ghana, most children below the ages of 5 years depending on the severity of the infection often lose their lives. However, it is still debatable why infection with falciparum malaria contributes to thrombocytopenia.

methodsThis study sought to investigate the expression of the various platelet indices and activation markers in children with falciparum malaria. Platelet indices (Platelet count [PLT], Plateletcrite [PCT], Mean Platelet Volume [MPV], Platelet Distribution Width [PDW] and Platelet-Large Cell Ratio [P-LCR]) and platelet surface membrane glycoproteins (GPIIb/IIIa [PAC-1], P-selectin [CD62p] and GPIV [CD36]) expressions were determined in children with falciparum malaria (cases) and healthy children (controls) using automated blood cell analysis and flow cytometry techniques, respectively.

resultsExcept for P-LCR, all the other platelet indices (PLT, MPV, PDW, and PCT) were significantly lower in the cases than the controls (P < 0.05). Also, it was observed that the level of expression of the activation markers; PAC 1 and CD62p showed a significant (P < 0.05) decreased before and after activation in falciparum malaria cases than in the controls. On the contrary, CD36 expression in the controls did not differ significantly (p > 0.05) from the malaria cases. Platelet activation markers were known to be associated with increased risk of falciparum malaria with the mean fluorescence intensity of PAC1 (Odds Ratio [OR] 34.0, Relative Risk [RR] 4.47, 95% Confidence Interval [CI] 4.904-235.7; p < 0.0001) and CD36 (OR 4.2, RR 1.82, 95% CI 0.9824-17.96; p = 0.04). Moreover, the percentage expression of CD62p (OR 4.0, RR 1.80, 95% CI 0.59-27.24; p = 0.19) was also observed to be probably associated with increased risk of falciparum malaria although not statistically significant (p > 0.05).

conclusionPlasmodium falciparum malaria has been known to be associated with platelet activation markers, which probably contributes to thrombocytopenia.

Indexed as

Hematologic TestsPlatelet ActivationAdolescentBiomarkersBlood PlateletsCase-Control StudiesChildChild, PreschoolFemaleFlow CytometryGhanaHumansMalaria, FalciparumMaleP-SelectinBiomarkersP-SelectinSELP protein, humanFlow cytometryPlasmodium falciparumPlatelet indicesPlatelet membrane glycoproteins

Identifiers

PMID32268918
PMCPMC7140500
OpenAlexW3015839881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.