ArticleMalaria journal2020
Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination.
Article in Malaria journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Spatiotemporal differentiation of Plasmodium vivax populations in the western Greater Mekong Subregion using a 22-SNP barcode.PLoS neglected tropical diseases · 2026Article
- Genetic diversity and multiplicity of Plasmodium spp. infections in Southeast Asia: a scoping review.Osong public health and research perspectives · 2026Article
- Hotspot districts of persistentThe Lancet regional health. Southeast Asia · 2025Article
- Plasmodium vivax populations in the western Greater Mekong Subregion evaluated using a genetic barcode.PLoS neglected tropical diseases · 2024Article
- Multidisciplinary Investigations of Sustained Malaria Transmission in the Greater Mekong Subregion.The American journal of tropical medicine and hygiene · 2022Article
- Genetic diversity of Plasmodium vivax reticulocyte binding protein 2b in global parasite populations.Parasites & vectors · 2022Article
- Population genomics in neglected malaria parasites.Frontiers in microbiology · 2022Review
- Temporal Changes in the Genetic Diversity ofPathogens (Basel, Switzerland) · 2021Article
- A retrospective analysis of malaria epidemiological characteristics in Yingjiang County on the China-Myanmar border.Scientific reports · 2021Article
- Genetic Diversity and Natural Selection ofFrontiers in microbiology · 2021Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundCountries within the Greater Mekong Sub-region (GMS) of Southeast Asia have committed to eliminating malaria by 2030. Although the malaria situation has greatly improved, malaria transmission remains at international border regions. In some areas, Plasmodium vivax has become the predominant parasite. To gain a better understanding of transmission dynamics, knowledge on the changes of P. vivax populations after the scale-up of control interventions will guide more effective targeted control efforts.
methodsThis study investigated genetic diversity and population structures in 206 P. vivax clinical samples collected at two time points in two international border areas: the China-Myanmar border (CMB) (n = 50 in 2004 and n = 52 in 2016) and Thailand-Myanmar border (TMB) (n = 50 in 2012 and n = 54 in 2015). Parasites were genotyped using 10 microsatellite markers.
resultsDespite intensified control efforts, genetic diversity remained high (H
conclusionsWith enhanced control efforts on malaria, P. vivax at the TMB and CMB showed considerable spatial and temporal differentiation, but the presence of large P. vivax reservoirs still sustained genetic diversity and transmission. These findings provide new insights into P. vivax transmission dynamics and population structure in these border areas of the GMS. Coordinated and integrated control efforts on both sides of international borders are essential to reach the goal of regional malaria elimination.
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