Evidence map›Paper›PMID 32268786›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2020

Clopidogrel Resistance in a Murine Model of Diet-Induced Obesity Is Mediated by the Interleukin-1 Receptor and Overcome With DT-678.

Yifang Sun, Jessica Venugopal, Chiao Guo, Yanbo Fan, Jianping Li, Yanjun Gong, Y Eugene Chen, Haoming Zhang, Daniel T Eitzman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Pleiotropic effects of clopidogrel.Purinergic signalling · 2022
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yifang SunFrom the Department of Internal Medicine, Cardiovascular Research Center, University of Michigan Medical Center, Ann Arbor (Y.S., J.V., C.G., Y.F., Y.E.C., D.T.E.).
Jessica VenugopalFrom the Department of Internal Medicine, Cardiovascular Research Center, University of Michigan Medical Center, Ann Arbor (Y.S., J.V., C.G., Y.F., Y.E.C., D.T.E.).
Chiao GuoFrom the Department of Internal Medicine, Cardiovascular Research Center, University of Michigan Medical Center, Ann Arbor (Y.S., J.V., C.G., Y.F., Y.E.C., D.T.E.).
Yanbo FanFrom the Department of Internal Medicine, Cardiovascular Research Center, University of Michigan Medical Center, Ann Arbor (Y.S., J.V., C.G., Y.F., Y.E.C., D.T.E.).
Jianping LiDepartment of Cardiology, Peking University First Hospital, Beijing, China (J.L., Y.G.).
Yanjun GongDepartment of Cardiology, Peking University First Hospital, Beijing, China (J.L., Y.G.).
Y Eugene ChenFrom the Department of Internal Medicine, Cardiovascular Research Center, University of Michigan Medical Center, Ann Arbor (Y.S., J.V., C.G., Y.F., Y.E.C., D.T.E.).
Haoming ZhangDepartment of Pharmacology, University of Michigan, Ann Arbor (H.Z.).
Daniel T EitzmanFrom the Department of Internal Medicine, Cardiovascular Research Center, University of Michigan Medical Center, Ann Arbor (Y.S., J.V., C.G., Y.F., Y.E.C., D.T.E.).
University of Michigan–Ann Arbor · USAnn Arbor VA Medical Center · USPeking University · CN

Funding

The role of TFEB in aortic aneurysmsR01HL145176 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FAN, YANBO · 2019 to 2022
$2.2M
Transcription Factor-EB and Postischemic AngiogenesisR01HL138094 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FAN, YANBO · 2017 to 2021
$2.2M
Leukocyte Regulation of Vascular FunctionI01BX002776 · VA · VETERANS HEALTH ADMINISTRATION · PI EITZMAN, DANIEL T · 2016 to 2019
–
BLRD VA I01 BX002776NHLBI NIH HHS R01 HL138094NHLBI NIH HHS R01 HL145176
6 · The paper itself

Abstract

objectiveClopidogrel is a commonly used P2Y

conclusionsThese findings indicate that antiplatelet effects of clopidogrel may be impaired in the setting of diabetes mellitus due to reduced prodrug bioactivation related to IL-1 receptor signaling. Therapeutic targeting of P2Y

Indexed as

Drug ResistanceAnimalsCarotid Artery ThrombosisClopidogrelCytochrome P-450 Enzyme SystemDiabetes MellitusDiet, High-FatDisease Models, AnimalFibrinolytic AgentsGene ExpressionMaleMiceMice, Inbred C57BLMicrosomes, LiverObesityPlatelet AggregationClopidogrelCytochrome P-450 Enzyme SystemFibrinolytic AgentsPlatelet Aggregation InhibitorsProdrugsReceptors, Interleukin-1clopidogrelcytochromesdiabetes mellitusobesitythrombosis

Identifiers

PMID32268786
PMCPMC7296442
OpenAlexW3015786534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.