Evidence map›Paper›PMID 32268572›Full record

ArticleVaccines2020

Immunization against ROS1 by DNA Electroporation Impairs K-Ras-Driven Lung Adenocarcinomas ​.

Federica Riccardo, Giuseppina Barutello, Angela Petito, Lidia Tarone, Laura Conti, Maddalena Arigoni, Chiara Musiu, Stefania Izzo, Marco Volante, Dario Livio Longo and 4 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Federica RiccardoDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.ORCID 0000-0002-9692-0172
Giuseppina BarutelloDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.
Angela PetitoDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.ORCID 0000-0002-6038-9068
Lidia TaroneDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.
Laura ContiDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.ORCID 0000-0003-1780-098X
Maddalena ArigoniDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.
Chiara MusiuDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.
Stefania IzzoDepartment of Oncology, University of Torino, 10043 Orbassano, Italy.
Marco VolanteDepartment of Oncology, University of Torino, 10043 Orbassano, Italy.
Dario Livio LongoInstitute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), 10126 Torino, Italy.
Irene Fiore MerighiDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.
Mauro PapottiDepartment of Oncology, University of Torino, 10043 Orbassano, Italy.
Federica CavalloDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.ORCID 0000-0002-8151-9124
Elena QuaglinoDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.ORCID 0000-0003-4571-1060
University of Turin · ITInstitute of Biostructure and Bioimaging · IT

Funding

FINPIEMONTE, Digital tEchnology For Lung Cancer Treatment (DEFLeCT) 333-44Fondazione Ricerca Molinette 8893Università degli Studi di Torino RILO_2013
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is still the leading cause of cancer death worldwide. Despite the introduction of tyrosine kinase inhibitors and immunotherapeutic approaches, there is still an urgent need for novel strategies to improve patient survival. ROS1, a tyrosine kinase receptor endowed with oncoantigen features, is activated by chromosomal rearrangement or overexpression in NSCLC and in several tumor histotypes. In this work, we have exploited transgenic mice harboring the activated K-Ras oncogene (K-Ras

Indexed as

DNA plasmid electroporationNSCLCROS1

Identifiers

PMID32268572
PMCPMC7349290
OpenAlexW3016220820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.