ArticleThe American journal of medicine2020
Coronary Artery Calcium and the Age-Specific Competing Risk of Cardiovascular Versus Cancer Mortality: The Coronary Artery Calcium Consortium.
Article in The American journal of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Coronary artery calcium score of zero in individuals with diabetes: association with normal coronary arteries and cardiovascular risk factors.The international journal of cardiovascular imaging · 2026Article
- Opportunistic Screening on Chest CT, From theAJR. American journal of roentgenology · 2026Review
- Personalizing prevention for healthy cardiovascular aging: Geriatric cardiology in the 2024-2025 hypertension and dyslipidemia guidelines.American journal of preventive cardiology · 2026Article
- Early detection of cardiovascular disease in chest population screening: challenges for a rapidly emerging cardiac CT application.The British journal of radiology · 2025Review
- Cancer, genetic susceptibility and risk of coronary artery disease: A prospective study.American journal of preventive cardiology · 2025Article
- Major cardiovascular events in patients with cardiovascular monosodium urate deposits in atherosclerotic plaques.Rheumatology (Oxford, England) · 2025Article
- Coronary artery calcium and cardiovascular risk factors analysis after radiotherapy for breast cancer (the CLARIFIER: a gender-based preventive medicine study).Frontiers in cardiovascular medicine · 2025Article
- Polygenic Risk Scores and Extreme Coronary Artery Calcium Phenotypes (CAC=0 and CAC≥1000) in Adults ≥75 Years Old: The ARIC Study.Circulation. Cardiovascular imaging · 2024Article
- Coronary artery calcium is associated with increased risk for lung and colorectal cancer in men and women: the Multi-Ethnic Study of Atherosclerosis (MESA).European heart journal. Cardiovascular Imaging · 2022Article
- Etiology and Management of Dyslipidemia in Patients With Cancer.Frontiers in cardiovascular medicine · 2022Review
- Teaching an old dog new tricks: The prognostic role of CACS in hospitalized COVID-19 patients.Atherosclerosis · 2021Article
- Association between coronary artery calcium and cardiovascular disease as a supporting cause in cancer: The CAC consortium.American journal of preventive cardiology · 2020Article
- 20-Year trend of high prevalence of zero coronary artery calcium in beach cities of Southern California: A blue zone?American journal of preventive cardiology · 2020Article
- Coronary Artery Calcium Scoring: New Insights into Clinical Interpretation-Lessons from the CAC Consortium.Radiology. Cardiothoracic imaging · 2020Review
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Authors and funding
18 authors at 10 institutions in 2 countries.
Funding
Abstract
backgroundCoronary artery calcium (CAC) is a guideline recommended cardiovascular disease (CVD) risk stratification tool that increases with age and is associated with non-cardiovascular disease outcomes including cancer. We sought to define the age-specific change in the association between CAC and cause-specific mortality.
methodsThe Coronary Artery Calcium Consortium includes 59,502 asymptomatic patients age 40-75 without known CVD. Age-stratified mortality rates and parametric survival regression modeling was performed to estimate the age-specific CAC score at which CVD and cancer mortality risk were equal.
resultsThe mean age was 54±8 years (67% men) and there were 2,423 deaths over a mean 12±3 years follow-up. Among individuals with CAC = 0, cancer was the leading cause of death, with low CVD mortality rates for both younger (40-54 years) 0.2/1,000 person-years and older participants (65-75 years) 1.3/1,000 person-years. When CAC ≥400, CVD was consistently the leading cause of death among younger (71% of deaths) and older participants (56% of deaths). The CAC score at which CVD overtook cancer as the leading cause of death increased exponentially with age and was approximately 115 at age 50 and 380 at age 65.
conclusionsRegardless of age, when CAC = 0 cancer was the leading cause of death and the cardiovascular disease mortality rate was low. Our age-specific estimate for the CAC score at which CVD overtakes cancer mortality allows for a more precise approach to synergistic prediction and prevention strategies for CVD and cancer.
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