Evidence map›Paper›PMID 32268129›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2020

Topical application of bacteriophages for treatment of wound infections.

Rachel Yoon Kyung Chang, Sandra Morales, Yuko Okamoto, Hak-Kim Chan

Open access · greenAbstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Phage as a prospective arsenal against superbugs.Molecular biology reports · 2026
    Review
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  11. Article
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  18. Chitosan-based matrix as a carrier for bacteriophages.Applied microbiology and biotechnology · 2024
    Article
  19. Review
  20. Bacteriophage therapy reducesAntimicrobial agents and chemotherapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Rachel Yoon Kyung ChangAdvanced Drug Delivery Group, The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, New South Wales, Australia.
Sandra MoralesPhage Consulting, Sydney, New South Wales, Australia.
Yuko OkamotoFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Hak-Kim ChanAdvanced Drug Delivery Group, The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, New South Wales, Australia. Electronic address: kim.chan@sydney.edu.au.
The University of Sydney · AUSojo University · JP

Funding

Harnessing bacteriophages as natural predators to combat the superbugs: a pulmonary drug delivery approachR33AI121627 · NIAID · UNIVERSITY OF SYDNEY · PI CHAN, KIM · 2018 to 2020
$598k
NIAID NIH HHS R33 AI121627
6 · The paper itself

Abstract

Wound infections associated with multidrug-resistant (MDR) bacteria are one of the important threats to public health. Bacteriophage (phage) therapy is a promising alternative or supplementary therapeutic approach to conventional antibiotics for combating MDR bacterial infections. In recent years, significant effort has been put into the development of phage formulations and delivery methods for topical applications, along with preclinical and clinical uses of phages for the treatment of acute and chronic wound infections. This paper reviews the application of phages for wound infections, with focus on the current status of phage formulations (including liquid, semi-solid and liposome-encapsulated formulations, phage-immobilized wound dressings), safety and efficacy assessment in clinical settings and major challenges to overcome.

Indexed as

BandagesDrug Resistance, Multiple, BacterialHumansLab-On-A-Chip DevicesLiposomesPhage TherapyWound InfectionLiposomes

Identifiers

PMID32268129
PMCPMC7293950
OpenAlexW3011655561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.