Evidence map›Paper›PMID 32268100›Full record

ArticleCell reports2020

NKT Cells Join the Two Step for Inflammasome-Independent IL-1β Release.

Jelena S Bezbradica, Sebastian Joyce

Abstract readComment
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jelena S BezbradicaThe Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. Electronic address: jelena.bezbradica@kennedy.ox.ac.uk.
Sebastian JoyceDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA; Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Centre, Nashville, TN 37232, USA. Electronic address: sebastian.joyce@vumc.org.

Funding

Molecular Basis of CD1D and Natural Killer T Cell FunctionR01AI137082 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JOYCE, SEBASTIAN · 2019 to 2022
$2.1M
Processing and Presentation of Minor Histocompatibility Antigens that Cause GvHDR01HL121139 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JOYCE, SEBASTIAN · 2014 to 2017
$1.6M
Vaccinating at Mucosal Surfaces with Nanoparticle Conjugated Antigen and AdjuvantI01BX001444 · VA · VETERANS HEALTH ADMINISTRATION · PI JOYCE, SEBASTIAN · 2014 to 2022
–
BLRD Research Career Scientist Award ApplicationIK6BX004595 · VA · VETERANS HEALTH ADMINISTRATION · PI JOYCE, SEBASTIAN · 2019 to 2025
–
BLRD VA I01 BX001444BLRD VA I01 BX006010BLRD VA IK6 BX004595Medical Research Council MR/S000623/1NHLBI NIH HHS R01 HL121139NIAID NIH HHS R01 AI137082
6 · The paper itself

Abstract

The cytokine interleukin-1β (IL-1β) is critical for antimicrobial defenses; the inflammasome pathway typically controls IL-1β release, but pathogens often evade this pathway. In this issue, Donado et al. (2020) describe an alternative, two-cell model, to instruct inflammasome-independent IL-1β release.

Indexed as

InflammasomesNatural Killer T-CellsCytokinesInterleukin-1betaCytokinesInflammasomesInterleukin-1beta

Identifiers

PMID32268100
PMCPMC7770951

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.