ReviewEnvironmental science. Processes & impacts2020
A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health.
Review in Environmental science. Processes & impacts, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
108 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Changes in soil microbial communities after exposure to neonicotinoids: A systematic review.Environmental microbiology reports · 2023Pooled it
- Effects of dinotefuran and its metabolites on the early life stage development of medaka (Toxicology reports · 2026Article
- Ameliorating Effect of Continuous Treatment With an Amorphous Formula of Curcumin on Maternal Imidacloprid Exposure-Induced Suppression of Hippocampal Neurogenesis in Rats.Environmental toxicology · 2026Article
- Improved Removal of Neonicotinoid Insecticides from Real Water Matrices by Modified UF and NF Membranes.Membranes · 2026Article
- A Quinoline-Benzimidazole Probe for Efficient Detection of Imidacloprid: Mechanisms and Applications.Molecules (Basel, Switzerland) · 2026Article
- Pesticides-induced cellular toxicity in the spinal cord cell line of Lates calcarifer.In vitro cellular & developmental biology. Animal · 2026Article
- Field-deployable supramolecular fluorescent sensing platform for selective dual-mode detection of thiamethoxam in complex environmental matrices.Mikrochimica acta · 2026Article
- Functional Expression of Nicotinic Receptors on iPSC-Derived Astrocytes and Signalling Disturbances by a Panel of Neonicotinoid Pesticides and Their Metabolites.International journal of molecular sciences · 2026Article
- Advances in Enantioselective Synthesis and Chiral Resolution of Insecticides.Molecules (Basel, Switzerland) · 2026Review
- Occurrence of insecticides, fungicides, and herbicides in household drinking and irrigation water in an intensive floriculture region of Ecuador.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Behavioral disruption in honey bees (Apis mellifera) exposed to isolated and combined insecticides.Ecotoxicology (London, England) · 2026Article
- Development and validation of matrix-validated LC-MS/MS method for simultaneous quantification of 21 neonicotinoids and their metabolites in human urine.Environmental science and pollution research international · 2026Article
- Evaluating a Novel Method to Limit Non-Target Mortality in Attractive Toxic Sugar Bait Systems.Insects · 2026Article
- Bacterial Resilience and Vulnerability to Neonicotinoid Seed Treatments in Soil: Short-Term Community Responses.Environmental microbiology reports · 2026Article
- Sublethal Clothianidin Exposure Impairs Development, Thyroid Hormones, Locomotion and Predation inToxics · 2026Article
- Article
- Clashing in Murky Waters: On Amphibian Mosquito Suppression.Ecology and evolution · 2026Article
- Exposing the Airway Surface to the Neonicotinoid Clothianidin Alters the Electrophysiological Properties of Human Airway Epithelia.ACS omega · 2026Article
- High-Throughput Toxicity Screening withEnvironmental science & technology · 2026Review
- Neonicotinoids and the Androgen Receptor: Structural Dynamics and Potential Signaling Disruption.Biology · 2026Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Neonicotinoid insecticides are widely used in both urban and agricultural settings around the world. Historically, neonicotinoid insecticides have been viewed as ideal replacements for more toxic compounds, like organophosphates, due in part to their perceived limited potential to affect the environment and human health. This critical review investigates the environmental fate and toxicity of neonicotinoids and their metabolites and the potential risks associated with exposure. Neonicotinoids are found to be ubiquitous in the environment, drinking water, and food, with low-level exposure commonly documented below acceptable daily intake standards. Available toxicological data from animal studies indicate possible genotoxicity, cytotoxicity, impaired immune function, and reduced growth and reproductive success at low concentrations, while limited data from ecological or cross-sectional epidemiological studies have identified acute and chronic health effects ranging from acute respiratory, cardiovascular, and neurological symptoms to oxidative genetic damage and birth defects. Due to the heavy use of neonicotinoids and potential for cumulative chronic exposure, these insecticides represent novel risks and necessitate further study to fully understand their risks to humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.