ArticleAstrobiology2020
Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions.
Article in Astrobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Continuous UV irradiation played an inconclusive role in selecting the canonical genetic alphabet.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- On-Demand Photoprotection by UV-Transparent Small Molecules via Aggregation-Induced Absorption: The Origin and Modern Application.ACS central science · 2026Article
- Prebiotic chemistry and protocells during the faint young sun event.Biophysical reviews · 2024Article
- Prebiotic synthesis of dihydrouridine by photoreduction of uridine in formamide.Chemical communications (Cambridge, England) · 2024Article
- Photochemistry of 2-thiooxazole: a plausible prebiotic precursor to RNA nucleotides.Physical chemistry chemical physics : PCCP · 2022Article
- Protometabolism as out-of-equilibrium chemistry.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Review
- UV Transmission in Natural Waters on Prebiotic Earth.Astrobiology · 2022Article
- Shielding from UV Photodamage: Implications for Surficial Origins of Life Chemistry on the Early Earth.ACS earth & space chemistry · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A previously proposed synthesis of pyrimidine ribonucleotides makes use of ultraviolet (UV) light to convert β-d-ribocytidine-2',3'-cyclic phosphate to β-d-ribouridine-2',3'-cyclic phosphate, while simultaneously selectively degrading synthetic byproducts. Past studies of the photochemical reactions of pyrimidines have employed mercury arc lamps, characterized by narrowband emission centered at 254 nm, which is not representative of the UV environment of the early Earth. To further assess this process under more realistic circumstances, we investigated the wavelength dependence of the UV-driven conversion of β-d-ribocytidine-2',3'-cyclic phosphate to β-d-ribouridine-2',3'-cyclic phosphate. We used constraints provided by planetary environments to assess the implications for pyrimidine nucleotides on the early Earth. We found that the wavelengths of light (255-285 nm) that most efficiently drive the deamination of β-d-ribocytidine-2',3'-cyclic phosphate to β-d-ribouridine-2',3'-cyclic phosphate are accessible on planetary surfaces such as those of the Hadean-Archaean Earth for CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.