Evidence map›Paper›PMID 32267726›Full record

ArticleAstrobiology2020

Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments.

Amelia K Pollard, Christopher J Gaffney, Colleen S Deane, Michele Balsamo, Michael Cooke, Rebecca A Ellwood, Jennifer E Hewitt, Beata E Mierzwa, Alessandro Mariani, Siva A Vanapalli and 2 more

Abstract readValidation Study
In one paragraph

Article in Astrobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. iScience · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amelia K PollardMRC Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, University of Nottingham, Medical School Royal Derby Hospital, Derby, United Kingdom.
Christopher J GaffneySport and Health Sciences, University of Exeter, Exeter, United Kingdom.
Colleen S DeaneSport and Health Sciences, University of Exeter, Exeter, United Kingdom.
Michele BalsamoKayser Italia, Livorno, Italy.
Michael CookeMRC Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, University of Nottingham, Medical School Royal Derby Hospital, Derby, United Kingdom.
Rebecca A EllwoodMRC Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, University of Nottingham, Medical School Royal Derby Hospital, Derby, United Kingdom.
Jennifer E HewittDepartment of Chemical Engineering, Texas Tech University, Lubbock, Texas.
Beata E MierzwaDepartment of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California.
Alessandro MarianiKayser Italia, Livorno, Italy.
Siva A VanapalliDepartment of Chemical Engineering, Texas Tech University, Lubbock, Texas.
Timothy EtheridgeSport and Health Sciences, University of Exeter, Exeter, United Kingdom.
Nathaniel J SzewczykMRC Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, University of Nottingham, Medical School Royal Derby Hospital, Derby, United Kingdom.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Biotechnology and Biological Sciences Research Council BB/N015894/1Biotechnology and Biological Sciences Research Council BB/P025781/1Medical Research Council MR/T026014/1NIH HHS P40 OD010440
6 · The paper itself

Abstract

Biology experiments in space seek to increase our understanding of what happens to life beyond Earth and how we can safely send life beyond Earth. Spaceflight is associated with many (mal)adaptations in physiology, including decline in musculoskeletal, cardiovascular, vestibular, and immune systems. Biological experiments in space are inherently challenging to implement. Development of hardware and validation of experimental conditions are critical to ensure the collection of high-quality data. The model organism

Indexed as

Adaptation, PhysiologicalSpace FlightAnimalsCaenorhabditis elegansCardiovascular DeconditioningEquipment DesignExobiologyModels, AnimalMusclesWeightlessnessWeightlessness SimulationAstrobiologyC. elegans—Space biologySpaceflight

Identifiers

PMID32267726
PMCPMC7415877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.