ArticleJournal of veterinary internal medicine2020
Assessment of postoperative adjuvant treatment using toceranib phosphate against adenocarcinoma in dogs.
Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Surgery and toceranib for renal cell carcinoma with caval thrombus in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2026Article
- Complete Response to the Combination of Immunotherapy and Targeted Therapy in Stage IV Nasal Adenocarcinoma of a Dog: A Case Report.Veterinary medicine and science · 2026Article
- PDGFRβ Expression Across Canine AGASAC Subtypes and Metastases: Morphologic Insights and Possible Therapeutic Implications.Veterinary sciences · 2025Article
- Long-term management of mandibular osteosarcoma in a dog using toceranib after hemimandibulectomy.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Clinical Utility of Patient-Derived Cell-Based In Vitro Drug Sensitivity Testing for Optimizing Adjuvant Therapy in Dogs with Solid Tumors: A Retrospective Study (2019-2023).Animals : an open access journal from MDPI · 2025Article
- Exposure-Response Relationships for Toceranib in Dogs with Solid Tumors: A Pilot Study.Animals : an open access journal from MDPI · 2025Article
- Is There Anything New in Canine AGASACA?Veterinary sciences · 2024Review
- Retrospective Safety Evaluation of Combined Chlorambucil and Toceranib for the Treatment of Different Solid Tumours in Dogs.Animals : an open access journal from MDPI · 2024Article
- Immunohistochemistry Screening of Different Tyrosine Kinase Receptors in Canine Solid Tumors-Part I: Proposal of a Receptor Panel to Predict Therapies.International journal of molecular sciences · 2024Article
- Phenotypic and molecular characterization of novel pulmonary adenocarcinoma cell lines established from a dog.Scientific reports · 2023Article
- Toceranib phosphate and firocoxib-mediated partial response in a dog with advanced intranasal sarcoma.The Journal of veterinary medical science · 2023Article
- Case report: Adjuvant therapy with toceranib for an incompletely resected renal cell carcinoma with suspected pulmonary metastasis in a dog.Frontiers in veterinary science · 2023Article
- Induction of autophagy improves skin and hair conditions in dogs with underlying diseases.Frontiers in veterinary science · 2023Article
- Article
- Toceranib phosphate in the management of canine insulinoma: A retrospective multicentre study of 30 cases (2009-2019).Veterinary record open · 2022Article
- Transarterial chemoembolisation for palliative treatment of renal cell carcinoma in two dogs with pulmonary metastasis.The Journal of small animal practice · 2022Article
- Canine Gastric Cancer: Current Treatment Approaches.Veterinary sciences · 2022Review
- Autologous blood pleurodesis for surgical pneumothorax and outcome with multimodal cancer treatment in a dog with primary pulmonary mast cell tumor.Clinical case reports · 2022Article
- Clinical and histopathological features and prognosis of gastrointestinal adenocarcinomas in Jack Russell Terriers.The Journal of veterinary medical science · 2021Article
- Gene expression of prostaglandin EP4 receptor in three canine carcinomas.BMC veterinary research · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToceranib phosphate (TOC) could be made widely available for treating tumors in dogs if evidence shows that TOC inhibits recurrence after surgery.
objectivesTo investigate how postoperative adjuvant treatment with TOC modulates the tumor microenvironment (TME), by assessing effects on angiogenic activity, tumor-infiltrating regulatory T cells (Tregs), and intratumoral hypoxia. ANIMALS: Ninety-two client-owned dogs were included: 28 with apocrine gland anal sac adenocarcinoma, 24 with small intestinal adenocarcinoma, 22 with lung adenocarcinoma, and 18 with renal cell carcinoma.
methodsRetrospective, multicenter study comparing time to progression (TTP) between 42 dogs treated by surgery and TOC and 50 dogs treated by surgery alone. Differences were analyzed in the expression of vascular endothelial growth factor receptor-2 (VEGFR2) and the number of Foxp3
resultsMedian TTP for dogs treated by surgery and TOC (360 days) was higher than that for dogs treated by surgery alone (298 days; hazard ratio, 0.82; 95% confidence interval [CI], 0.65-0.96; P = .02). In dogs treated by surgery and TOC, VEGFR2 expression and the number of Tregs and HIF-1α CONCLUSIONS AND CLINICAL IMPORTANCE: Toceranib phosphate could prove to be a useful postoperative adjuvant treatment because of its modulation of the TME.
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