ArticleThe EMBO journal2020
A microtubule polymerase is required for microtubule orientation and dendrite pruning in Drosophila.
Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- The conserved microtubule-associated protein Mini Spindles promotes dendrite branching and limits terminal branch elongation inmicroPublication biology · 2026Article
- Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes.Science advances · 2025Article
- Glial-derived TNF/Eiger signaling promotes somatosensory neurite sculpting.Cellular and molecular life sciences : CMLS · 2025Article
- Recent progress in dendritic pruning ofOpen biology · 2024Review
- Patronin regulates presynaptic microtubule organization and neuromuscular junction development iniScience · 2024Article
- Droj2 Facilitates Somatosensory Neurite Sculpting via GTP-Binding Protein Arf102F inInternational journal of molecular sciences · 2023Article
- Establishment of a novel axon pruning model of Drosophila motor neuron.Biology open · 2023Article
- Article
- A fly's eye view of quiescent neural stem cells.Oxford open neuroscience · 2022Review
- A systematic analysis of microtubule-destabilizing factors during dendrite pruning in Drosophila.EMBO reports · 2021Article
- Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells.The EMBO journal · 2021Article
- Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons.PLoS genetics · 2021Article
- A microtubule polymerase is required for microtubule orientation and dendrite pruning in Drosophila.The EMBO journal · 2020Article
- Homeostatic Roles of the Proteostasis Network in Dendrites.Frontiers in cellular neuroscience · 2020Review
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6 authors at 1 institution in 1 country.
Funding
Abstract
Drosophila class IV ddaC neurons selectively prune all larval dendrites to refine the nervous system during metamorphosis. During dendrite pruning, severing of proximal dendrites is preceded by local microtubule (MT) disassembly. Here, we identify an unexpected role of Mini spindles (Msps), a conserved MT polymerase, in governing dendrite pruning. Msps associates with another MT-associated protein TACC, and both stabilize each other in ddaC neurons. Moreover, Msps and TACC are required to orient minus-end-out MTs in dendrites. We further show that the functions of msps in dendritic MT orientation and dendrite pruning are antagonized by the kinesin-13 MT depolymerase Klp10A. Excessive MT depolymerization, which is induced by pharmacological treatment and katanin overexpression, also perturbs dendritic MT orientation and dendrite pruning, phenocopying msps mutants. Thus, we demonstrate that the MT polymerase Msps is required to form dendritic minus-end-out MTs and thereby promotes dendrite pruning in Drosophila sensory neurons.
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