ArticleJournal of applied oral science : revista FOB2020
miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis.
Article in Journal of applied oral science : revista FOB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- DNA and RNA Methylation in Periodontal and Peri-implant Diseases.Journal of dental research · 2025Review
- Methylome and transcriptome analyses reveal HLA-DMB's contribution to periodontitis development.PloS one · 2025Article
- TNF-α promoter hypomethylation is frequent in oncopediatric patients who recovered from mucositis.Brazilian oral research · 2024Observational
- The rosetta stone of successful ageing: does oral health have a role?Biogerontology · 2023Review
- Mild elevation of C-reactive protein in a young patient with severe periodontitis: a case report with 2 years of follow-up.The Journal of international medical research · 2022Article
- DNMT3B (rs2424913) polymorphism is associated with systemic lupus erythematosus alone and with co-existing periodontitis in a Brazilian population.Journal of applied oral science : revista FOB · 2022Article
- Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells.Stem cells international · 2022Review
- Emerging role of epigenetic regulations in periodontitis: a literature review.American journal of translational research · 2022Review
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic and epigenetic changes have been associated with periodontitis in various genes; however, little is known about genes involved in epigenetic mechanisms and in oxidative stress.
objectiveThis study aims to investigate the association of polymorphisms C677T in MTHFR (rs1801133) and -149C→T in DNMT3B (rs2424913), as well as the methylation profiles of MTHFR, miR-9-1, miR-9-3, SOD1, and CAT with periodontitis. The association between polymorphisms and DNA methylation profiles was also analyzed. METHODOLOGY: The population studied was composed of 100 nonsmokers of both sexes, divided into healthy and periodontitis groups. Genomic DNA was extracted from the epithelial buccal cells, which were collected through a mouthwash. Polymorphism analysis was performed through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while methylation-specific PCR (MSP) or combined bisulfite restriction analysis techniques were applied for methylation analysis.
resultsFor DNMT3B, the T allele and the TT genotype were detected more frequently in the periodontitis group, as well as the methylated profile on the miR-9-1 promoter region. There was also a tendency towards promoter region methylation on the CAT sequence of individuals with periodontal disease.
conclusionThe polymorphism -149C→T in DNMT3B (rs2424913) and the methylated profile of the miR-9-1 promoter region are associated with periodontitis.
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