Evidence map›Paper›PMID 32267197›Full record

ArticleMolecular biology of the cell2020

Optical flow analysis reveals that Kinesin-mediated advection impacts the orientation of microtubules in the

Maik Drechsler, Lukas F Lang, Layla Al-Khatib, Hendrik Dirks, Martin Burger, Carola-Bibiane Schönlieb, Isabel M Palacios

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Maik DrechslerSchool of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK.
Lukas F LangDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, United Kingdom.
Layla Al-KhatibSchool of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK.
Hendrik DirksInstitute for Computational and Applied Mathematics, University of Münster, 48149 Münster, Germany.
Martin BurgerDepartment of Mathematics, Friedrich-Alexander Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
Carola-Bibiane SchönliebDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, United Kingdom.
Isabel M PalaciosSchool of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK.
Queen Mary University of London · GBUniversity of Cambridge · GBFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The orientation of microtubule (MT) networks is exploited by motors to deliver cargoes to specific intracellular destinations and is thus essential for cell polarity and function. Reconstituted in vitro systems have largely contributed to understanding the molecular framework regulating the behavior of MT filaments. In cells, however, MTs are exposed to various biomechanical forces that might impact on their orientation, but little is known about it. Oocytes, which display forceful cytoplasmic streaming, are excellent model systems to study the impact of motion forces on cytoskeletons in vivo. Here we implement variational optical flow analysis as a new approach to analyze the polarity of MTs in the

Indexed as

ActinsAnimalsBiomechanical PhenomenaCell PolarityCytoplasmCytoplasmic StreamingCytoskeletonDrosophila melanogasterDrosophila ProteinsDyneinsFemaleKinesinsMechanical PhenomenaMicrotubulesOocytesOptic FlowActinsDrosophila ProteinsDyneinsKinesins

Identifiers

PMID32267197
PMCPMC7353148
OpenAlexW3015068359

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.