SynthesisAddiction biology2021
A meta-analysis of tract-based spatial statistics studies examining white matter integrity in cocaine use disorder.
Synthesis in Addiction biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- White matter alterations in mild cognitive impairment revealed by meta-analysis of diffusion tensor imaging using tract-based spatial statistics.Brain imaging and behavior · 2023Pooled it
- Gray-white matter covarying impairment in the anterior cingulate cortex revealed by multimodal meta-analysis of post-stroke cognitive impairment.Frontiers in aging neuroscience · 2026Article
- Alcohol-Induced Changes in Brain Microstructure: Uncovering Novel Pathophysiological Mechanisms of AUD Using Translational DTI in Humans and Rodents.Current topics in behavioral neurosciences · 2025Review
- Frontal White Matter Changes and Craving Recovery in Inpatients With Heroin Use Disorder.JAMA network open · 2024Article
- Neuroimaging Biomarkers in Addiction.medRxiv : the preprint server for health sciences · 2024Article
- FRONTAL WHITE MATTER CHANGES INDICATE RECOVERY WITH INPATIENT TREATMENT IN HEROIN ADDICTION.medRxiv : the preprint server for health sciences · 2024Article
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Non-local diffusion-based biomarkers in patients with cocaine use disorder.Neuroimage. Reports · 2024Article
- Comparison of three magnetic resonance imaging measures of brain iron in healthy and cocaine use disorder participants.NMR in biomedicine · 2024Article
- Structural projections to the nucleus accumbens link to impulsive components of human risk preference.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Cocaine Use Prediction With Tensor-Based Machine Learning on Multimodal MRI Connectome Data.Neural computation · 2023Article
- Chronic Cocaine Use and White Matter Coherence: A Diffusion Tensor Imaging Study.Journal of studies on alcohol and drugs · 2023Article
- Whole-brain white matter abnormalities in human cocaine and heroin use disorders: association with craving, recency, and cumulative use.Molecular psychiatry · 2023Article
- Article
- Brain tract structure predicts relapse to stimulant drug use.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mercury levels in hair are associated with reduced neurobehavioral performance and altered brain structures in young adults.Communications biology · 2022Article
- Strengthened and posterior-shifted structural rich-club organization in people who use cocaine.Drug and alcohol dependence · 2022Article
- The Mexican magnetic resonance imaging dataset of patients with cocaine use disorder: SUDMEX CONN.Scientific data · 2022Article
- White matter microstructure differences in individuals with dependence on cocaine, methamphetamine, and nicotine: Findings from the ENIGMA-Addiction working group.Drug and alcohol dependence · 2022Article
- Targeting white matter neuroprotection as a relapse prevention strategy for treatment of cocaine use disorder: Design of a mechanism-focused randomized clinical trial.Contemporary clinical trials · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI) studies have consistently shown diminished white matter (WM) integrity for individuals with cocaine use disorder (CUD). The present study used seed-based d mapping (SDM) to determine the extent to which a systematic difference in the WM integrity of cocaine users may exist (as compared with that of healthy controls). Articles from 2006 (when TBSS was first developed) to present were reviewed, with eight selected for inclusion. Meta-analysis found lower fractional anisotropy (FA) in the genu of the corpus callosum for cocaine users, with a small-to-moderate peak effect size (Hedge's g = -0.331). Sensitivity analyses mostly supported the robustness of the obtained difference. Differences detected at exploratory thresholds for significance suggested insult to WM integrity extending beyond the corpus callosum. The present results compliment a previous region-of-interest (ROI)-based meta-analysis of DTI studies in individuals with CUD. These findings have significant implications for the potential role of neuroprotective agents in the treatment of CUD and merit additional iteration as more studies accrue in the literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.