ArticleVeterinary medicine and science2020
Genetic variation of Brucella isolates at strain level in Egypt.
Article in Veterinary medicine and science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Animal Brucellosis in Egypt: Review on Evolution, Epidemiological Situation, PrevalentMicroorganisms · 2025Review
- Comprehensive epidemiological evaluation of ruminant brucellosis and associated risk factors in some Egyptian Governorates.Veterinary world · 2024Article
- First seroprevalence and molecular identification report ofVeterinary world · 2023Article
- Isolation and molecular confirmation of Brucella suis biovar 2 from slaughtered pigs: an unanticipated biovar from domestic pigs in Egypt.BMC veterinary research · 2022Article
- Risk factors and Molecular genotyping ofOne health (Amsterdam, Netherlands) · 2021Article
- Tracking the Distribution ofMicroorganisms · 2021Article
- Validation of real-time polymerase chain reaction versus conventional polymerase chain reaction for diagnosis of brucellosis in cattle sera.Veterinary world · 2021Article
- Genetic variation of Brucella isolates at strain level in Egypt.Veterinary medicine and science · 2020Article
- MLVA-16 Genotyping ofPathogens (Basel, Switzerland) · 2020Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, Multiple Locus Variable Number Tandem Repeat Analysis (MLVA-16) was performed on 18 Brucella isolates identified bacteriologically and molecularly (AMOS-PCR) as Brucella abortus (n = 6) and Brucella melitensis (n = 12). This was aimed to study the genetic association among some Egyptian Brucella genotypes isolated during the period from 2002 to 2013 along with the global genotypes database. MLVA-16 analysis for B. melitensis and B. abortus strains illustrates a total of 11, and 3 genotypes with 10 and 1 singleton genotypes, respectively. B. melitensis strains displayed greater markers diversity by VNTRs analysis of the 16 loci than B. abortus and this was attributed mainly to the diverging in panel 2B markers. B. melitensis genotype M4_Fayoum_Giza (3,5,3,13,1,1,3,3,8,21,8,7,5,9,5,3) was the only predominated genotype circulating between two different governorates. The most common B. abortus genotype, GT A3_Dakahlia (4,5,4,12,2,2,3,3,6,21,8,4,4,3,4,4), was present in three identical isolates. In phylogeny, Egyptian B. abortus bv1 genotypes were closely related to East Asian strain (for the first time), Western Mediterranean and Americas clonal lineages. B. melitensis local genotypes exhibit a genetic relatedness mostly to Western Mediterranean clonal lineage and one strain of Eastern Mediterranean clonal lineage. In conclusion, the geographic location is not the only factor stands behind the high genetic similarity of the Egyptian Brucella genotypes. These low variations may be a result of a stepwise mutational event of the most variable loci from a very limited number of ancestors especially during the transmission through non-preference hosts. The authors encourage the authorities in charge to establish pre-movement testing to reduce the risk of brucellosis spread.
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