ArticleEnvironmental science and pollution research international2020
Dietary exposure to polyvinyl chloride microparticles induced oxidative stress and hepatic damage in Clarias gariepinus (Burchell, 1822).
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 103 citations in OpenAlex.
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- Emerging threat of environmental microplastics: A comprehensive analysis of hepatic metabolic dysregulation and hepatocellular damage (Review).International journal of molecular medicine · 2025Review
- Impact of polyvinyl chloride nano-plastics on the biochemical status of Oreochromis niloticus under a predicted global warming scenario.Scientific reports · 2025Article
- A Dangerous Couple: Sequential Effect of Phosphorus Flame-Retardant and Polyurethane Decrease Locomotor Activity in PlanarianBiology · 2024Article
- Dietary intake of microplastics impairs digestive performance, induces hepatic dysfunction, and shortens lifespan in the annual fish Nothobranchius guentheri.Biogerontology · 2023Article
- Species-specific effects of microplastics on juvenile fishes.Frontiers in physiology · 2023Article
- Dose-Dependent Cytotoxicity of Polypropylene Microplastics (PP-MPs) in Two Freshwater Fishes.International journal of molecular sciences · 2022Article
- Review
- The Pressing Issue of Micro- and Nanoplastic Contamination: Profiling the Reproductive Alterations Mediated by Oxidative Stress.Antioxidants (Basel, Switzerland) · 2022Review
- Genotoxicity, oxidative stress and lysozyme induction in Clarias gariepinus chronically exposed to water-soluble fraction of burnt tire ash.Ecotoxicology (London, England) · 2021Article
- Toxicity and Functional Tissue Responses of Two Freshwater Fish after Exposure to Polystyrene Microplastics.Toxics · 2021Article
- Detoxification and recovery after cadmium exposure in the freshwater crab Sinopotamon henanense.Environmental science and pollution research international · 2021Article
- Sublethal diclofenac induced oxidative stress, neurotoxicity, molecular responses and alters energy metabolism proteins in Nile tilapia, Oreochromis niloticus.Environmental science and pollution research international · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the effects of polyvinyl chloride (PVC) microparticles (MP) on hepatic antioxidant enzymes activities, serum biochemical and liver histology of juvenile Clarias gariepinus. A total of 180 (25.15 g average weight) C. gariepinus were fed PVC MP (95.41 ± 4.23 μm) spiked diets at 0.5, 1.5, 3.0 percentage inclusion levels and a control diet for 45 days of exposure, then followed by 30 days of depuration trials. Fish specimens (9) from each treatment were sampled every 15-day interval for serum biochemical, liver antioxidant enzymes and histopathological assay. Glucose and triglyceride levels increased significantly in PVC-treated groups when compared with the control. Protein levels of 0.5% and 3.0% PVC-treated groups reduced significantly on the 15th and 30th day exposure periods, while serum enzyme activities of all PVC-treated groups increased significantly in a time-dependent manner. Antioxidant enzymes (superoxide dismutase, glutathione peroxidase, catalase) activity in the liver of the treated groups also decreased progressively in a time-dependent manner. A time-dependent elevation in lipid peroxidation levels was observed in PVC MP-treated groups. Histopathological assessment of the fish liver showed mild to severe levels of glycogen depletion, fatty vacuolation and degeneration, hepatocellular necrosis in PVC-treated groups with reference to the control. The present study revealed that PVC microplastic induced oxidative damage and hepatic histopathological alterations in the exposed fish.
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