Evidence map›Paper›PMID 32266232›Full record

ArticleFrontiers in bioengineering and biotechnology2020

A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data.

Ni Kou, Wenyang Zhou, Yuzhu He, Xiaoxia Ying, Songling Chai, Tao Fei, Wenqi Fu, Jiaqian Huang, Huiying Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Association between DPP6 gene rs10260404 polymorphism and increased risk of sporadic amyotrophic lateral sclerosis (sALS): a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ni KouDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Dalian, China.
Wenyang ZhouSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Yuzhu HeDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Dalian, China.
Xiaoxia YingDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Dalian, China.
Songling ChaiDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Dalian, China.
Tao FeiDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Dalian, China.
Wenqi FuDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Dalian, China.
Jiaqian HuangDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Dalian, China.
Huiying LiuDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Dalian, China.
Dalian Medical University · CNHarbin Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 level on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (-0.001; 95% CI-0.002 to 0;

Indexed as

casual effectgenome-wide association studiesInterleukin-18Mendelian randomizationOsteoporosis

Identifiers

PMID32266232
PMCPMC7099043
OpenAlexW3012034861

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.