Evidence map›Paper›PMID 32266168›Full record

ArticleFrontiers in cellular and infection microbiology2020

Pharmacophore-Based Virtual Screening Toward the Discovery of Novel Anti-echinococcal Compounds.

Congshan Liu, Jianhai Yin, Jiaqing Yao, Zhijian Xu, Yi Tao, Haobing Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 36 citations in OpenAlex.

  1. Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Review
  2. A Potential ABA Analog to Increase Drought Tolerance inInternational journal of molecular sciences · 2023
    Article
  3. Article
  4. Review
  5. Article
  6. A systematic strategy for the investigation of vaccines and drugs targeting bacteria.Computational and structural biotechnology journal · 2020
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Congshan LiuKey Laboratory of Parasite and Vector Biology, Chinese Center for Disease Control and Prevention, National Center for International Research on Tropical Diseases, WHO Collaborating Centre for Tropical Diseases, National Institute of Parasitic Diseases, MOH, Shanghai, China.
Jianhai YinKey Laboratory of Parasite and Vector Biology, Chinese Center for Disease Control and Prevention, National Center for International Research on Tropical Diseases, WHO Collaborating Centre for Tropical Diseases, National Institute of Parasitic Diseases, MOH, Shanghai, China.
Jiaqing YaoKey Laboratory of Parasite and Vector Biology, Chinese Center for Disease Control and Prevention, National Center for International Research on Tropical Diseases, WHO Collaborating Centre for Tropical Diseases, National Institute of Parasitic Diseases, MOH, Shanghai, China.
Zhijian XuDrug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Yi TaoKey Laboratory of Parasite and Vector Biology, Chinese Center for Disease Control and Prevention, National Center for International Research on Tropical Diseases, WHO Collaborating Centre for Tropical Diseases, National Institute of Parasitic Diseases, MOH, Shanghai, China.
Haobing ZhangKey Laboratory of Parasite and Vector Biology, Chinese Center for Disease Control and Prevention, National Center for International Research on Tropical Diseases, WHO Collaborating Centre for Tropical Diseases, National Institute of Parasitic Diseases, MOH, Shanghai, China.
National Institute for Parasitic Diseases · CNShanghai Institute of Materia Medica · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Echinococcosis is a serious helminthic zoonosis with a great impact on human health and livestock husbandry. However, the clinically used drugs (benzimidazoles) have a low cure rate, so alternative drugs are urgently needed. Currently, drug screenings for echinococcosis are mainly phenotype-based, and the efficiency of identifying active compounds is very low. With a pharmacophore model generated from the structures of active amino alcohols, we performed a virtual screening to discover novel compounds with anti-echinococcal activity. Sixty-two compounds from the virtual screening were tested on

Indexed as

EchinococcosisEchinococcus multilocularisAlbendazoleAnimalsDrug Evaluation, PreclinicalMebendazoleMiceAlbendazoleMebendazolecytotoxicityechinococcosisEchinococcus multilocularisE. multilocularis-infected micein vitro drug screenpharmacokinetics analysispharmacophore modelingvirtual screenings

Identifiers

PMID32266168
PMCPMC7098963
OpenAlexW3012418482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.