ReviewF1000Research2020
Diagnostic and therapeutic options in recurrent implantation failure.
Review in F1000Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Optimizing the Endometrial Factor in Recurrent Implantation Failure: From Established Diagnostics to Mechanism-Informed Management.Journal of clinical medicine · 2026Review
- Endometrial elasticity in infertile women assessed by transvaginal shear wave elastography.Quantitative imaging in medicine and surgery · 2026Article
- Shedding light on the function of autophagy in complicated pregnancies.Cell death & disease · 2026Review
- Aberrant progesterone receptor (PGR) expression is associated with estrogen receptor 1 (ESR1) expression in the endometrium from infertile women with endometriosis.Molecular human reproduction · 2026Article
- Impact of hysteroscopy on pregnancy outcomes in women with endometriosis-associated infertility undergoing their first frozen-thawed embryo transfer: a retrospective cohort study.Frontiers in medicine · 2026Article
- PTN/IGF-2 signaling modulates endometrial decidualization and immune cell trafficking to facilitate pregnancy maintenance.Frontiers in immunology · 2026Article
- Sequential blastocyst transfer improved pregnancy outcomes in patients undergoing frozen-thawed embryo transfer cycles: who will be the ultimate beneficiary.Frontiers in endocrinology · 2026Article
- Molecular subtype of recurrent implantation failure reveals distinct endometrial etiology of female infertility.Journal of translational medicine · 2025Article
- Endometrial stromal Menin supports endometrial receptivity by maintaining homeostasis of WNT signaling pathway through H3K4me3 during WOI.Communications biology · 2025Article
- Endometrial echo patterns of embryo transfer day affect pregnancy outcomes in frozen embryo transfer cycles: a retrospective clinical study.BMC pregnancy and childbirth · 2025Article
- Review
- Review
- Chronic endometritis incidence in infertile women with and without polycystic ovary syndrome: a propensity score matched study.BMC women's health · 2023Article
- Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications.Journal of personalized medicine · 2023Review
- Endometrial Staining of CD56 (Uterine Natural Killer), BCL-6, and CD138 (Plasma Cells) Improve Diagnosis and Clinical Pregnancy Outcomes in Unexplained Infertility and Recurrent IVF Failures: Standardization of Diagnosis with Digital Pathology.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- The Dynamics of miR-449a/c Expression during Uterine Cycles Are Associated with Endometrial Development.Biology · 2022Article
- The outcomes of sequential embryo transfer in patients undergoing in vitro fertilization with frozen-thawed embryos: A retrospective study.The journal of obstetrics and gynaecology research · 2022Article
- Is There any Role for Granulocyte Colony Stimulating Factor in Improvement of Implantation in Intrauterine Insemination? A Prospective Double-Blind Randomized Control Trial.International journal of fertility & sterility · 2022Article
- TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NF-κB signaling pathway.Reproductive biology and endocrinology : RB&E · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent implantation failure (RIF) is an uncommon, imprecisely defined clinical disorder characterized by failure to achieve pregnancy after repeated embryo transfers. The diverse etiologies and incomplete understanding of RIF provide significant diagnostic and therapeutic challenges to patients and providers. Careful clinical evaluation prior to assisted reproduction can uncover many treatable causes, including thyroid dysfunction, submucosal myomas, and tobacco use. The more-subtle causes often require a more-targeted assessment. Undetected, small polyps or small areas of intrauterine synechiae are relatively common and easily treated contributors to RIF. Molecular and cellular abnormalities pose a greater therapeutic challenge. Putative causes of RIF, including progesterone resistance, shifted window of receptivity, decreased integrin expression, and immunologic disturbances, should be considered in the evaluation of a patient with otherwise unexplained RIF. It may also be true that a more complex and standardized definition of RIF would be helpful in these cases. In this paper, we review the diagnostic and therapeutic approaches to RIF, with emphasis on disorders of endometrial receptivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.