Evidence map›Paper›PMID 32265929›Full record

ArticleFrontiers in immunology2020

Rapid Induction and Maintenance of Virus-Specific CD8

Nancy Graham, Phil Eisenhauer, Sean A Diehl, Kristen K Pierce, Stephen S Whitehead, Anna P Durbin, Beth D Kirkpatrick, Alessandro Sette, Daniela Weiskopf, Jonathan E Boyson and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Dengue and severe dengue.Clinical microbiology reviews · 2025
    Review
  4. CD4Vaccines · 2025
    Article
  5. Human T Cell Responses to Flavivirus Vaccines.European journal of immunology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Nancy GrahamDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Phil EisenhauerVaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Sean A DiehlDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Kristen K PierceVaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Stephen S WhiteheadLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Anna P DurbinBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Beth D KirkpatrickDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, United States.
Daniela WeiskopfDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, United States.
Jonathan E BoysonDepartment of Surgery, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Jason W BottenDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
University of Vermont · USJohns Hopkins University · USLa Jolla Institute for Immunology · USNational Institute of Allergy and Infectious Diseases · USUniversity of California, San Diego · US

Funding

Clinical Trials of Biodefense Vaccines (Dengue, West Nile Virus, TBEV)ZIAAI000987 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI WHITEHEAD, STEPHEN · 2009 to 2025
$37.9M
T Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus VaccinationP01AI106695 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Eva Harris · 2015 to 2026
$34.1M
Using Dengue Controlled Human Infection Model to Identify Adaptive Immune Correlates of ProtectionP20GM125498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kristen Pierce · 2018 to 2026
$24.9M
Vermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8M
Mechanisms of Protection and Durability for a Live Attenuated Tetravalent Dengue VaccineU01AI141997 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Sean A. Diehl, Anna Palmer Durbin · 2019 to 2026
$5.1M
Upgrade of a FACS Aria Cell SorterS10OD018175 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOYSON, JONATHAN E · 2015 to 2015
$153k
NIAID NIH HHS HHSN272200900010CNIAID NIH HHS HHSN272201400045CNIAID NIH HHS P01 AI106695NIAID NIH HHS U01 AI141997NIGMS NIH HHS P20 GM125498NIGMS NIH HHS P30 GM118228NIH HHS S10 OD018175
6 · The paper itself

Abstract

Dengue virus (DENV) is a mosquito-borne flavivirus that causes serious human disease. The current lack of an effective vaccine to simultaneously protect against the four serotypes of DENV in seronegative individuals is a major unmet medical need. Further, the immunological basis for protective immunity in the setting of DENV infection or vaccination is not fully understood. Our team has developed a live attenuated tetravalent dengue virus vaccine that provides complete protection in a human model of dengue virus challenge. The goal of this study was to define, in the context of protective human vaccination, the quality of vaccine-induced DENV-specific CD8

Indexed as

T-Cell Antigen Receptor SpecificityAntibodies, NeutralizingAntibodies, ViralAntigens, ViralCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesClinical Trials, Phase I as TopicCytokinesDengue VaccinesDengue VirusEpitopesHumansImmunization, SecondaryImmunogenicity, VaccineImmunologic MemoryLeukocyte Common AntigensAntibodies, NeutralizingAntibodies, ViralAntigens, ViralCytokinesDengue VaccinesEpitopesLeukocyte Common AntigensVaccines, AttenuatedCD4CD8denguehuman challengememoryprotective immunityTEMRAvaccine

Identifiers

PMID32265929
PMCPMC7105617
OpenAlexW3013309344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.