Evidence map›Paper›PMID 32265901›Full record

ArticleFrontiers in immunology2020

EuroFlow Standardized Approach to Diagnostic Immunopheneotyping of Severe PID in Newborns and Young Children.

Tomas Kalina, Marina Bakardjieva, Maartje Blom, Martin Perez-Andres, Barbara Barendregt, Veronika Kanderová, Carolien Bonroy, Jan Philippé, Elena Blanco, Ingrid Pico-Knijnenburg and 14 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

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  9. Future Perspectives of Newborn Screening for Inborn Errors of Immunity.International journal of neonatal screening · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 10 institutions in 6 countries.

Tomas KalinaDepartment of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia.
Marina BakardjievaDepartment of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia.
Maartje BlomLaboratory for Immunology, Department of Pediatrics, Leiden University Medical Center (LUMC), Leiden, Netherlands.
Martin Perez-AndresDepartment of Medicine-Serv. Cytometry, Cancer Research Center (IBMCC-CSIC/USAL), University of Salamanca, Salamanca, Spain.
Barbara BarendregtDepartment of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Veronika KanderováDepartment of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia.
Carolien BonroyDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Jan PhilippéDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Elena BlancoDepartment of Medicine-Serv. Cytometry, Cancer Research Center (IBMCC-CSIC/USAL), University of Salamanca, Salamanca, Spain.
Ingrid Pico-KnijnenburgLaboratory for Immunology, Department of Pediatrics, Leiden University Medical Center (LUMC), Leiden, Netherlands.
Jitse H M P PapingLaboratory for Immunology, Department of Pediatrics, Leiden University Medical Center (LUMC), Leiden, Netherlands.
Beata Wolska-KuśnierzDepartment of Immunology, Children's Memorial Health Institute, Warsaw, Poland.
Malgorzata PacDepartment of Immunology, Children's Memorial Health Institute, Warsaw, Poland.
Jakub TkazcykDepartment of Pediatrics, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia.
Filomeen HaerynckPID Research Lab, Department of Pediatric Pulmonology and Immunology, Ghent University Hospital, Ghent, Belgium.
Himmet Haluk AkarDepartment of Pediatric Immunology and Allergy, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul Health Sciences University, Istanbul, Turkey.
Renata FormánkováDepartment of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia.
Tomáš FreibergerCentre for Cardiovascular Surgery and Transplantation, Brno, Czechia.
Michael SvatoňDepartment of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia.
Anna ŠediváDepartment of Immunology, University Hospital Motol, Prague, Czechia.
Sonia Arriba-MéndezServicio de Pediatría, Hospital Universitario de Salamanca, Salamanca, Spain.
Alberto OrfaoDepartment of Medicine-Serv. Cytometry, Cancer Research Center (IBMCC-CSIC/USAL), University of Salamanca, Salamanca, Spain.
Jacques J M van DongenDepartment of Immunohematology and Blood Transfusion (IHB), Leiden University Medical Center (LUMC), Leiden, Netherlands.
Mirjam van der BurgLaboratory for Immunology, Department of Pediatrics, Leiden University Medical Center (LUMC), Leiden, Netherlands.
University Hospital in Motol · CZLeiden University Medical Center · NLGhent University Hospital · BEUniversidad de Salamanca · ESChildren's Memorial Health Institute · PLErasmus MC · NLCentrum kardiovaskulární a transplantační chirurgie · CZCharles University · CZComplejo Hospitalario de Salamanca · ESİstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The EuroFlow PID consortium developed a set of flow cytometry tests for evaluation of patients with suspicion of primary immunodeficiency (PID). In this technical report we evaluate the performance of the SCID-RTE tube that explores the presence of recent thymic emigrants (RTE) together with T-cell activation status and maturation stages and discuss its applicability in the context of the broader EuroFlow PID flow cytometry testing algorithm for diagnostic orientation of PID of the lymphoid system. We have analyzed peripheral blood cells of 26 patients diagnosed between birth and 2 years of age with a genetically defined primary immunodeficiency disorder: 15 severe combined immunodeficiency (SCID) patients had disease-causing mutations in

Indexed as

Child, PreschoolFemaleFlow CytometryHLA-DR AntigensHumansImmunophenotypingInfantInfant, NewbornMalePrimary Immunodeficiency DiseasesSevere Combined ImmunodeficiencyThymus GlandT-LymphocytesHLA-DR AntigensdiagnosisEuroFlowflow cytometric immunophenotypingprimary immunodeficiencies (PID)severe combined immune deficiency (SCID)standardization

Identifiers

PMID32265901
PMCPMC7096355
OpenAlexW3011873898

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.