Evidence map›Paper›PMID 32265718›Full record

ArticleFrontiers in pharmacology2020

Muscone Ameliorates Ovariectomy-Induced Bone Loss and Receptor Activator of Nuclear Factor-κb Ligand-Induced Osteoclastogenesis by Suppressing TNF Receptor-Associated Factor 6-Mediated Signaling Pathways.

Xiao Zhai, Zijun Yan, Jian Zhao, Kai Chen, Yilin Yang, Mengxi Cai, Chen He, Chunyou Huang, Bo Li, Mingyuan Yang and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Xiao ZhaiDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Zijun YanGraduate Management Unit, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Jian ZhaoDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Kai ChenDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Yilin YangDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Mengxi CaiGraduate Management Unit, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Chen HeGraduate Management Unit, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Chunyou HuangGraduate Management Unit, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Bo LiDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Mingyuan YangDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Xiaoyi ZhouDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Yingchuan ZhaoDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Xiaozhao WeiDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Yushu BaiDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Ming LiDepartment of Orthopedics, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China.
Changhai Hospital · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postmenopausal osteoporosis is caused by the deficiency of estrogen, which breaks bone homeostasis and induces levels of pro-inflammatory cytokines. Muscone is a potent anti-inflammatory agent and is used to treat bone fracture in traditional Chinese medicine. However, its anti-osteoclastogenic effects remain unclear. For

Indexed as

musconeosteoclastspostmenopausal osteoporosisRANKTRAF6

Identifiers

PMID32265718
PMCPMC7099619
OpenAlexW3012069030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.